Evolution of Left Ventricular Mass in Renal Transplant Recipients: The Influence of Glucose Homeostasis and Oxidative Stress

Osorio, J.M.; Marfil, Almudena Pérez; Ferreyra, C.; Abúd, R. Pérez; Fuentes, M.C. Ruiz; Galindo, Pilar; Gracia, M.C. de; Osuna, Antonio

doi:10.1016/j.transproceed.2012.07.086

Cited by 2 publications

(5 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…evaluated 25 patients who underwent kidney transplant and 25 patients who remained on the waiting list with cardiac magnetic resonance over a mean time period of 2.4 to 2.8 years and saw no significant difference in the change in LV mass index between groups. However, consistent with our findings, other studies support that LV mass decreases following kidney transplant . Rigatto et al.…”

Section: Discussionsupporting

confidence: 93%

“…performed a prospective study evaluating LV mass index in 143 transplant recipients over a 4‐year period and observed that LV mass index decreased significantly over the first 2 years after transplant, but plateaued over the third and fourth year. Other reports that have described an improvement in LV mass following transplant have a limited cohort size (<45 patients) or are retrospective in study design . Given the long duration of follow‐up in our study evaluating a large prospective cohort, our findings strengthen the evidence describing an improvement in LV mass after kidney transplantation.…”

Section: Discussionsupporting

confidence: 81%

“…[14][15][16][17][18] year. Other reports that have described an improvement in LV mass following transplant have a limited cohort size (<45 patients) 8,10,29,30 or are retrospective in study design. 28 Given the long duration of follow-up in our study evaluating a large prospective cohort, our findings strengthen the evidence describing an improvement in LV mass after kidney transplantation.…”

Section: Discussionmentioning

confidence: 99%

“…The increased LV mass in ESRD patients secondary to myocardial hypertrophy is a function of an enlargement of the LV end‐diastolic diameter and increased LV wall thickness. While several reports indicate that LV mass improves following kidney transplant, this has not been universally observed in all kidney transplant patients …”

Section: Introductionmentioning

confidence: 91%

See 3 more Smart Citations

Longitudinal assessment of cardiac morphology and function following kidney transplantation

Kensinger

Hernandez

Bian

et al. 2016

Clinical Transplantation

View full text Add to dashboard Cite

Background Abnormal cardiac morphology is a risk factor for cardiovascular complications in kidney transplant patients. A supraphysiologic level of fibroblast growth factor 23 (FGF-23) has been associated with myocardial hypertrophy in this patient population. Our aim was to evaluate the change in cardiac morphology and function following kidney transplantation and to evaluate the association between the change in FGF-23 concentrations and cardiac morphology. Methods We performed a longitudinal, prospective cohort study of 143 kidney transplant recipients (73% male, 75% white) measuring left ventricular (LV) mass index, left atrial (LA) volume index, and ejection fraction (EF) by echocardiography at months 1, 12, and 24 post-transplant. FGF-23 levels were measured at months 1 and 24 post-transplant. Results Unadjusted and adjusted linear mixed effects models were used to examine changes in outcomes over time. In the adjusted model, LV mass index (P<0.001) and LA volume index (P<0.001) decreased and EF (P=0.009) increased significantly over time. There was a significant association between decreasing FGF-23 levels and improving LV mass index following transplant (P=0.036) in the unadjusted model; however, there was no significant relationship in the adjusted model (0.195). Conclusion Understanding the progression of unique cardiovascular risk factors associated with kidney transplantation may provide potential opportunities to improve survival.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

See 2 more Smart Citations

Longitudinal assessment of cardiac morphology and function following kidney transplantation

Kensinger

Hernandez

Bian

et al. 2016

Clinical Transplantation

View full text Add to dashboard Cite

show abstract

“…The other important factors were pretransplant hemodialysis therapy, episodes of acute rejection, cumulative steroid dose, and anemia [25]. In the recently published prospective study on 37 adult renal transplant recipients without diabetes, the evolution of LVM after transplant was influenced by glucose metabolism disorders, markers of oxidative stress, and kidney graft function [26]. …”

Section: Discussionmentioning

confidence: 99%

The Association of Long-Functioning Hemodialysis Vascular Access with Prevalence of Left Ventricular Hypertrophy in Kidney Transplant Recipients

Kolonko

Kujawa-Szewieczek

Szotowska

et al. 2014

BioMed Research International

View full text Add to dashboard Cite

Left ventricular hypertrophy (LVH) is frequently observed in chronic dialysis patients and is also highly prevalent in kidney transplant recipients. This study evaluates the impact of long-functioning hemodialysis vascular access on LVH in single center cohort of kidney transplant recipients. 162 patients at 8.7 ± 1.8 years after kidney transplantation were enrolled. Echocardiography, carotid ultrasound, and assessment of pulse wave velocity were performed. LVH was defined based on left ventricular mass (LVM) indexed for body surface area (BSA) and height2.7. There were 67 patients with and 95 without patent vascular access. Both study groups were comparable with respect to gender, age, duration of dialysis therapy, and time after transplantation, kidney graft function, and cardiovascular comorbidities. Patients with patent vascular access were characterized by significantly elevated LVM and significantly greater percentage of LVH, based on LVMI/BSA (66.7 versus 48.4%, P = 0.02). OR for LVH in patients with patent vascular access was 2.39 (1.19–4.76), P = 0.01. Regression analyses confirmed an independent contribution of patent vascular access to higher LVM and increased prevalence of LVH. We concluded that long-lasting patent hemodialysis vascular access after kidney transplantation is associated with the increased prevalence of LVH in kidney transplant recipients.

show abstract

Evolution of Left Ventricular Mass in Renal Transplant Recipients: The Influence of Glucose Homeostasis and Oxidative Stress

Cited by 2 publications

References 17 publications

Longitudinal assessment of cardiac morphology and function following kidney transplantation

Longitudinal assessment of cardiac morphology and function following kidney transplantation

The Association of Long-Functioning Hemodialysis Vascular Access with Prevalence of Left Ventricular Hypertrophy in Kidney Transplant Recipients

Contact Info

Product

Resources

About