2011
DOI: 10.1159/000328435
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Evolution of Leptin Structure and Function

Abstract: Leptin, the protein product of the obese(ob or Lep) gene, is a hormone synthesized by adipocytes that signals available energy reserves to the brain, and thereby influences development, growth, metabolism and reproduction. In mammals, leptin functions as an adiposity signal: circulating leptin fluctuates in proportion to fat mass, and it acts on the hypothalamus to suppress food intake. Orthologs of mammalian Lep genes were recently isolated from several fish and two amphibian species, and here we report the i… Show more

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Cited by 203 publications
(189 citation statements)
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References 286 publications
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“…Leptin, the protein product of the obese (ob or Lep) gene, was first cloned in ob/ob mice [1], and then was identified in human and other mammals (reviewed in [2]). Leptins also were identified in non-mammalians, including birds [3][4][5], reptiles [2], amphibians [6][7][8], and teleosts, the later generally possess duplicated leptins [8][9][10][11][12][13][14][15].…”
Section: Introductionmentioning
confidence: 99%
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“…Leptin, the protein product of the obese (ob or Lep) gene, was first cloned in ob/ob mice [1], and then was identified in human and other mammals (reviewed in [2]). Leptins also were identified in non-mammalians, including birds [3][4][5], reptiles [2], amphibians [6][7][8], and teleosts, the later generally possess duplicated leptins [8][9][10][11][12][13][14][15].…”
Section: Introductionmentioning
confidence: 99%
“…Leptins also were identified in non-mammalians, including birds [3][4][5], reptiles [2], amphibians [6][7][8], and teleosts, the later generally possess duplicated leptins [8][9][10][11][12][13][14][15]. Leptin has been found to be responsible for the regulation of body weight and energy homeostasis [16,17], and it also is involved in regulating appetite, reproduction [18], the immune system [19], bone formation [20], angiogenesis [21], and stress response [22,23].…”
Section: Introductionmentioning
confidence: 99%
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“…It is capable of increasing oestrogen production through the stimulation of aromatase expression and activity in luteinized granulosa cells and adipocytes (Catalano et al 2003). The leptin receptor is expressed in the brain and several other tissues such as liver, stomach, kidney and immune cells (Denver et al 2011;Xu et al 2012). Leptin acts on multiple brain regions including the brain stem, hypothalamus, hippocampus and ventral tegmental area by activating the cytokine type 1 leptin receptor which is coupled to the JAK2 signalling mechanism (Trinko et al 2011).…”
mentioning
confidence: 99%