Evolution of leukotriene B4, peptide leukotrienes, and interleukin-8 plasma concentrations in patients at risk of acute respiratory distress syndrome and with acute respiratory distress syndrome: Mortality prognostic study

Abstract

LTs are elevated during the early phases of ARDS, whereas IL-8 increases throughout the study. The evaluation of LTB4 and IL-8 may be useful prognostic indices in patients with early phase ARDS after admission to the intensive care unit.

Leukotriene B4 indicates lung injury and on-going inflammatory changes after severe trauma in a porcine long-term model

“…In line with these findings, lately increased LTB4 levels in the BAL fluid were associated with enhanced pulmonary infiltration with neutrophils as well as IL-8 expression. Previously, a close association of increased IL-8 and LTB4 levels has been proposed as useful prognostic indices in patients with early phase ARDS after admission to the intensive care unit [23,25]. Nonetheless, the role of LTB4 in trauma has not been fully elucidated.…”

“…Several studies have reported elevated levels of LTB4 also in bronchoalveolar lavage (BAL) fluid from patients with ARDS or other inflammatory lung diseases such as COPD [21][22][23][24]. Moreover, the evaluation of LTB4 and IL-8 has been described as useful prognostic indices in patients with early phase ARDS after admission to the intensive care unit [23,25]. With regard to trauma patients, the data is sparse.…”

Eicosanoids as Risk and Prognostic Factors for Acute Respiratory Distress Syndrome in Sepsis Patients

“…In contrast, ketoconazole was not found to reduce the mortality or duration of mechanical ventilation in a randomized trial [20]. The beneficial effects of ketoconazole may be attributed to the inhibition of leukotriene formation as well as thromboxane A 2 synthesis [7]. The results of the present study revealed that the likelihood value of the TXB 2 levels was higher than those of the other eicosanoids examined, and that TXA 2 is a prognostic factor for sepsis patients with ARDS rather than a factor for treatments.…”

“…Amat et al [7] analyzed the leukotrienes LTB 4 , LTC 4 and LTD 4 , and reported that only the plasma concentration of LTB 4 on day 1 was a prognostic marker for ARDS, and that LTB 4 and interleukin-8 together could be useful markers of the mortality rate. Leukotriene antagonists, such as ONO-1078 [21], LY255283 [22] and ICI 198,615 [23], seemed to ameliorate the clinical outcome in models of LPS-induced acute lung injury.…”

“…Various inflammatory mediators lead to a critical event in the development of organ injury in the microvessels of organs, especially the lungs. Leukotrienes, thromboxanes and prostaglandins, collectively referred to as eicosanoids, have been reported to be involved in sepsis [1][2][3][4], burns [5] and ARDS [6,7]. Leukotrienes contribute to pulmonary edema by inducing neutrophil influx and activation and increasing vascular permeability.…”