Evolution of Luteoma in Intrasplenic Ovarian Grafts in the Guinea-Pig

Abstract

Images Figs. 13-17 Figs. 18-23 Figs. 24-29 Figs. 1-6 Figs. 7-12

The Hormonal Background of Ovarian Experimental Tumourigenesis in the Guinea-Pig

“…Haemorrhagic follicles were found in 7 out of 9 animals. There were large follicular cysts, large corpora lutea, nodules of luteal cells; but in none of the 9 animals could the condition be considered as luteomatous, comparable to what has been described with ovarian grafts in experiments of a similarly long duration but without the continuous action of oestradiol (Iglesias, Mardones and Lipschutz, 1953). In some grafts Wolffian cysts of a variable size were found.…”

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THE tumours which appear in the intrasplenic ovarian graft in castrated rats, mice, guinea-pigs or rabbits apparently are due to the uncontrolled gonadotrophic activity of the prehypophysis, the ovarian steroid hormones which normally control hypophysial activity being inactivated during their passage through the liver before reaching the general circulation (Iglesias, Mardones and Lipschutz, 1953). The most striking proof in favour of this explanation is given by the administration of ovarian hormones.

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“…When oestrogen is administered the intrasplenic ovarian graft in the castrated guinea-pig offers the aspect of a normal ovary; hemorrhagic follicles and irregular luteal cords or nodules so characteristic of the intrasplenic graft in the guinea-pig fail to appear and seemingly normal corpora lutea are present (Lipschutz, Iglesias, Bruzzone, Humerez and Peinaranda.. 1948). On the other hand, corpora lutea, but also luteomata, are counteracted when progesterone is administered for several months (Mardones, 1948;Iglesias, Lipschutz and Mardones, 1950; Mardones, Bruzzone, Iglesias and Lipschutz, 1951). In mice the ovarian tumours arising in intrasplenic grafts can be prevented when oestrogen or androgen is given (Li and Gardner, 1949).…”

“…For the purpose of this study the secretory activity of 15 intrasplenic grafts, as listed in Table I of our previous paper (Iglesias, Mardones and Lipschutz, 1953) has been checked by the histological examination of the vaginal mucosa. the uterus and the mammary glands.…”

Hyperplastic and Infiltrating Lesions of the Stomach in Guinea Pigs after Intramural Injection of 3-Methylcholanthrene

“…W e assum e t h a t th e genetical difference as to g astric tu m o r in th ese species m u st be expressed not in te rm s o f refra c to rin e ss, b u t o f a difference o f tim in g co n d itio n s, as has been d e m o n stra te d by th e in d u c tio n o fiu te o m a ta in in trasp len ic o v arian a u to g ra fts at 10 to 36 m o n th s [5], an d granulosa-cell tu m o r w ith m e ta sta sis only a t 5 years a fte r g raftin g [6].…”