2020
DOI: 10.1371/journal.ppat.1008276
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Evolution of microsporidia: An extremely successful group of eukaryotic intracellular parasites

Abstract: Microsporidia are obligate intracellular parasites that can infect a wide range of hosts. They cause death and disease in both humans and agriculturally important animals. They have also become a powerful model for understanding the evolution of intracellular parasites. Recent work has explored how microsporidia genomes have evolved, the evolutionary origins of microsporidia, and how microsporidia adapt to interact with their hosts.

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Cited by 113 publications
(116 citation statements)
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References 51 publications
(107 reference statements)
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“…Microsporidia are a large phylum of fungal-related parasites that infect most animal species 21 . These pathogens can be lethal to immunocompromised humans, and can cause huge economic losses by infecting agriculturally important animals such as honey bees, silk worms and shrimp 22 .…”
Section: Several Reports Have Described the Deposition Of Bacterial Cmentioning
confidence: 99%
“…Microsporidia are a large phylum of fungal-related parasites that infect most animal species 21 . These pathogens can be lethal to immunocompromised humans, and can cause huge economic losses by infecting agriculturally important animals such as honey bees, silk worms and shrimp 22 .…”
Section: Several Reports Have Described the Deposition Of Bacterial Cmentioning
confidence: 99%
“…(a) Microsporidia proteins. Phylogeny of sequenced microsporidia genomes was determined previously (Wadi & Reinke, 2020). Conservation was determined using OrthoMCL orthogroups which were previously calculated (Wadi & Reinke, 2020).…”
Section: Conclusion and Future Perspectivementioning
confidence: 99%
“…Phylogeny of sequenced microsporidia genomes was determined previously (Wadi & Reinke, 2020). Conservation was determined using OrthoMCL orthogroups which were previously calculated (Wadi & Reinke, 2020). Ortholog assignment was confirmed using BLAST, using a reciprocal E‐value of at least 10 −5 (Johnson et al, 2008).…”
Section: Conclusion and Future Perspectivementioning
confidence: 99%
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“…Microsporidia was the first parasite to have its genome sequenced, revealing the smallest eukaryotic genome with as few as ~2000 protein coding 2 genes 2,3 . Genome reduction results from the loss of many metabolic and regulatory genes, reduced non-coding DNA, and reduced gene sizes that encode for proteins smaller than their yeast orthlogs [4][5][6][7] . Microsporidia have also lost mitochondria and instead depend on reduced organelles known as mitosomes 8 .…”
Section: Introductionmentioning
confidence: 99%