Evolution of Mortality over Time in Patients Receiving Mechanical Ventilation

Esteban, Andrés; Frutos‐Vivar, Fernando; Muriel, Alfonso; Ferguson, Niall D.; Peñuelas, Óscar; Abraira, Víctor; Raymondos, Konstantinos; Ríos, Fernando; Nin, Nicolás; Apezteguía, Carlos; Violi, Damian A.; Thille, Arnaud W.; Brochard, Laurent; González, Marco; Villagómez, Asisclo; Hurtado, Javier; Davies, Andrew R.; Du, Bin; Maggiore, Salvatore Maurizio; Pelosi, Paolo; Soto, Luis; Tomicić, Vinko; D’Empaire, Gabriel; Matamis, Dimitrios; Abroug, Fékri; Moreno, Rui P.; Soares, Marco Antonio; Arabi, Yaseen M.; Sandi, Freddy; Jibaja, Manuel; Amin, Pravin; Koh, Younsuck; Kuiper, Michael; Bülow, Hans-Henrik; Zeggwagh, Amine Ali; Anzueto, Antonio

doi:10.1164/rccm.201212-2169oc

Cited by 564 publications

(476 citation statements)

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“…Mortality rates of patients with the acute respiratory distress syndrome (ARDS) are high [1,2]. Biological markers as well as disease severity scoring systems may be useful for risk stratification and the creation of homogenous patient groups in clinical trials [3].…”

Section: Introductionmentioning

confidence: 99%

Plasma suPAR as a prognostic biological marker for ICU mortality in ARDS patients

et al. 2015

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Purpose: We investigated the prognostic value of plasma soluble urokinase plasminogen activator receptor (suPAR) on day 1 in patients with the acute respiratory distress syndrome (ARDS) for intensive care unit (ICU) mortality and compared it with established disease severity scores on day 1. Methods: suPAR was determined batchwise in plasma obtained within 24 h after admission. Results: 632 ARDS patients were included. Significantly (P = 0.02) higher median levels of suPAR were found with increasing severity of ARDS: 5.9 ng/ml [IQR 3.1-12.8] in mild ARDS (n = 82), 8.4 ng/ml .0] in moderate ARDS (n = 333), and 9.0 ng/ml .0] in severe ARDS (n = 217). Non-survivors had higher median levels of suPAR [12.5 ng/ml (IQR 5.1-19.5) vs. 7.4 ng/ml (3.9-13.6), P \ 0.001]. The area under the receiver operator characteristic curve (ROC-AUC) for mortality of suPAR (0.62) was lower than the ROC-AUC of the APACHE IV score (0.72, P = 0.007), higher than that of the ARDS definition classification (0.53, P = 0.005), and did not differ from that of the SOFA score (0.68, P = 0.07) and the oxygenation index (OI) (0.58, P = 0.29). Plasma suPAR did not improve the discrimination of the established disease severity scores, but did improve net reclassification of the APACHE score (29 %), SOFA score (23 %), OI (38 %), and Berlin definition classification (39 %). Conclusion: As a single biological marker, the prognostic value for death of plasma suPAR in ARDS patients is low. Plasma suPAR, however, improves the net reclassification, suggesting a potential role for suPAR in ICU mortality prediction models.

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Section: Introductionmentioning

confidence: 99%

Plasma suPAR as a prognostic biological marker for ICU mortality in ARDS patients

et al. 2015

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“…Durch die mittlerweile weitverbreitete Anwendung der protektiven Beatmung mit einem Tidalvolumen von 6 ml/kgKG und der Begrenzung des Spitzendrucks auf 30 mbar sowie die Titration des positiven endexspiratorischen Drucks ("positive end-expiratory pressure", PEEP) konnten die durch mechanischen Stress der alveolokapillären Einheit induzierten pathologischen Veränderungen ("ventilator-associated lung injury", VALI, [3]) reduziert werden.…”

Section: Spontanatmung Im Entwöhnungsprozess Technische Spielerei Odeunclassified

Augmentierte Spontanatmung im Entwöhnungsprozess

Ragaller

2014

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“…Based on the results of the largest epidemiological multinational study on mechanical ventilation, 14 % of the 18,302 included patients required a tracheostomy during their stay in the intensive care unit [1]. Two recent meta-analyses found no significant impact of early compared with late tracheostomy on duration of mechanical ventilation, length of ICU stay, or mortality rate [2,3].…”

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confidence: 99%