Evolution of nerve conduction velocity in later childhood and adolescence

Lang, Heikki; Puusa, Asko; Hynninen, Pirkko; Kuusela, Vesa; Jäntti, V.; Sillanpää, Matti

doi:10.1002/mus.880080108

Cited by 40 publications

(26 citation statements)

References 9 publications

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“…While the duration of diabetes and treatment are included, many reports provide animal weight (usually 25–30 g) or state that they are mature. Data presented in this study document an increase in sural sensory NCV and sciatic motor NCV from 12 to 24 weeks of age in agreement with previous reports of increased velocity in rats, dogs and humans (12, 17, 29). …”

Section: Discussionsupporting

confidence: 93%

The effects of anesthesia on measures of nerve conduction velocity in male C57Bl6/J mice

Hayes

Sims‐Robinson

et al. 2010

Neuroscience Letters

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Animal models, particularly mice, are used extensively to investigate neurological diseases. Basic research regarding animal models of human neurological disease requires that the animals exhibit hall mark characteristics of the disease. These include disease specific anatomical, metabolic and behavioral changes. Nerve conduction velocity (NCV) is the predominant method used to assess peripheral nerve health. Normative data adjusted for age, gender and height is available for human patients; however, these data are not available for most rodents including mice. NCV may be affected by animal age and size, body temperature, stimulus strength and anesthesia. While the effects of temperature, age and size are documented, the direct and indirect effects of anesthesia on NCV are not well reported. Our laboratory is primarily concerned with animal models of diabetic neuropathy (DN) and uses NCV to confirm the presence of neuropathy. To ensure that subtle changes in NCV are reliably assayed and not directly or indirectly affected by anesthesia, we compared the effects of 4 commonly used anesthetics, isoflurane, ketamine/xylazine, sodium pentobarbital and 2-2-2 tribromoethanol on NCV in a commonly used rodent model, the C57Bl6/J mouse. Our results indicate that of the anesthetics tested, isoflurane has minimal impact on NCV and is the safest, most effective method of anesthesia. Our data strongly suggest that isoflurane should become the anesthetic of choice when performing NCV on murine models of neurological disease.

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Section: Discussionsupporting

confidence: 93%

The effects of anesthesia on measures of nerve conduction velocity in male C57Bl6/J mice

Hayes

Sims‐Robinson

et al. 2010

Neuroscience Letters

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“…[25][26][27][28] Hyperglycaemia itself may also play a role. Peripheral nerve function in humans matures to adult levels by late childhood and early adolescence 29 and animals with maturing peripheral nerves exposed to hyperglycaemia manifest greater pathological alterations than those that occur when adult nerves are exposed to similarly elevated glucose concentrations. 30 These studies raise the possibility that nerves are more susceptible to diabetes during the pubertal years.…”

Section: Discussionmentioning

confidence: 98%

Peripheral sensory nerve dysfunction in children and adolescents with Type 1 diabetes mellitus

Barkai¹,

Kempler

Vámosi³

et al. 1998

Diabet. Med.

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The aim of the present study was to investigate peripheral sensory nerve function in diabetic children and adolescents without neurological symptoms. Ninety-two children and adolescents with Type 1 (insulin-dependent) diabetes mellitus (mean +/- SD age: 14.2 +/- 2.1 years, diabetes duration: 5.8 +/- 3.0 years) and 80 healthy control subjects (age: 13.8 +/- 2.2 years) matched for age, sex, body mass index, and height standard deviation score were involved in the study. Using a sine-wave transcutaneous stimulator, current perception threshold (CPT) testing at 2000, 250 and 5 Hz was performed on the left median and peroneal nerves. Diabetic children had increased CPT at 2000 Hz on both nerves as compared to the control group (median (interquartile range), median nerve: 2.43 (2.20-3.43) vs 1.80 (1.51-2.60) mA, p = 0.02; peroneal nerve: 3.51 (2.81-4.82) vs 2.70 (2.04-3.70) mA, p = 0.01). Twenty-one (23%) of patients had CPT values higher than that of any healthy individual. Of these, elevated CPT was observed in 9 (9.8%) patients on the median nerve, in 8 (8.7%) patients on the peroneal nerve, and in 4 (4.3%) patients on both median and peroneal nerves. Using multiple logistic regression analysis, worse long-term metabolic control and advanced puberty were independently predictive of peripheral sensory nerve dysfunction as the dependent variable (adjusted OR (95% CI): 3.4 (1.2-6.2), p = 0.01, and 2.8 (1.1-5.6), p = 0.03, respectively). In conclusion, evidence of peripheral sensory nerve dysfunction is not rare in children and adolescents with diabetes and can be demonstrated by CPT testing in asymptomatic patients. Poor metabolic control is a risk factor for such subclinical neuropathy, and pubertal development may be involved in the pathogenesis of diabetic peripheral neuropathy.

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“…Possible candidates in healthy children include changes in innervation, muscle architecture and muscle contractile properties with growth (6;12;15;21). Upper extremities nerve conduction velocity increases with age in children and may be related to thinning of the distal compared to proximal portions of the axons as limbs grow in length (15). In adults the rate of maximal motor unit discharge, which declines with age and corresponds to the decline in muscle strength, may limit force production (21).…”

Section: Discussionmentioning

confidence: 99%

Attenuated Maximal Muscle Strength and Peak Power in Children With Sickle Cell Disease

Dougherty

Schall

Rovner

et al. 2011

Journal of Pediatric Hematology/Oncology

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Dominant hand maximal handgrip strength with a handgrip dynamometer and peak power with a force plate, adjusted for body size and composition were compared in 5-to 13-yr-old AfricanAmerican children with and without type SS sickle cell disease (SCD-SS). Children with SCD-SS (n = 35, 9.0 ± 2.0 yrs) compared to healthy controls (n = 103, 8.6 ± 1.8 yrs) did not differ by age, gender, or pubertal status, yet had significantly lower Z scores for height, weight, body mass index, upper arm muscle area, upper arm fat area, fat and lean mass-for-height. Children with SCD-SS had significantly lower handgrip strength (12.7 ± 3.3 vs. 15.2 ± 5.1 kg, P < 0.008), peak power (882 ± 298 vs. 1167 ± 384 W, P < 0.001) and growth and body composition adjusted Z scores for handgrip strength (0.6 ± 1.3 standard deviations, P < 0.004) and peak power (males = 1.0 ± 0.8, P < 0.0002; females = 1.0 ± 1.7, P < 0.006). Maximal muscle strength and peak power are attenuated in children with SCD-SS compared to controls beyond expectation for growth and body composition deficits suggesting additional factors contribute to the attenuation in anaerobic performance.

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Evolution of nerve conduction velocity in later childhood and adolescence

Cited by 40 publications

References 9 publications

The effects of anesthesia on measures of nerve conduction velocity in male C57Bl6/J mice

The effects of anesthesia on measures of nerve conduction velocity in male C57Bl6/J mice

Peripheral sensory nerve dysfunction in children and adolescents with Type 1 diabetes mellitus

Attenuated Maximal Muscle Strength and Peak Power in Children With Sickle Cell Disease

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