Evolution of Neurosensory Cells and Systems

Fritzsch, Bernd; Elliott, Karen L.

doi:10.1201/9781003092810

Cited by 2 publications

(3 citation statements)

References 201 publications

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“…In the basilar papilla of birds, tall HCs, mid-HCs, and short HCs are arranged in sequence from the proximal to distal ends of the cochlea (Fischer, 1994). The macula lagena, which is a particular structure in birds, is located at the distal end of the cochlear duct and has shown the presence of otoliths, which have previously been reported to be similar to those in the vestibular systems (Chagnaud et al, 2017;Fritzsch & Elliott, 2022). Similarities between the different structures exist in many aspects, including their size, shape, and elemental or cellular composition (Szeto et al, 2022).…”

Section: The Avian Inner Ear Is Different From the Mammalian Inner Earmentioning

confidence: 99%

“…In birds, these form a sickle shape, and the HCs and surrounding SCs form a chimeric arrangement with each HC having six SCs surrounding it, and all cells are arranged in one plane. The mammalian cochlea, in contrast, has a spiral shape (Fritzsch & Elliott, 2022) (Figures 2 and 4). In the basilar papilla of birds, tall HCs, mid-HCs, and short HCs are arranged in sequence from the proximal to distal ends of the cochlea (Fischer, 1994).…”

Section: The Avian Inner Ear Is Different From the Mammalian Inner Earmentioning

confidence: 99%

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Cross‐species analysis and comparison of the inner ear between chickens and mice

Zhang

Mao

et al. 2023

J of Comparative Neurology

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The inner ear of mammals includes the cochlea and vestibule, which house specialized hair cells that are responsible for hearing and balance, respectively. While cochlear hair cells fail to regenerate following damage, those of the utricle, which is part of the vestibular apparatus, show partial regeneration. In birds, the macula lagena, a unique ear structure in this clade, has the ability to regenerate hair cells similarly to the utricle. Many studies have sought to explain regeneration in terms of evolution and species differences. However, it remains unclear what the cellular and molecular basis is behind the differences in inner ear structures and between avians and mammals. In the present study, we first investigated the anatomical structures of the inner ear of both chickens and rodents. We then performed RNA sequencing (RNA‐Seq) and made cross‐species analyses of the expression of homologous genes obtained from the inner ear tissue from both chickens and mice. Finally, we focused on the lagena, the basilar papilla, and the utricle in chickens and identified differentially expressed genes between tissues and determined the expression patterns of genes involved in inner ear structure formation by single‐cell RNA sequencing and bulk RNA‐Seq. We concluded that the cellular and molecular composition of the lagena is more similar to that of the utricle than the cochlea. Taken together, our study provides a valuable resource for the study of inner ear evolution and development.

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Section: The Avian Inner Ear Is Different From the Mammalian Inner Earmentioning

confidence: 99%

Section: The Avian Inner Ear Is Different From the Mammalian Inner Earmentioning

confidence: 99%

Cross‐species analysis and comparison of the inner ear between chickens and mice

Zhang

Mao

et al. 2023

J of Comparative Neurology

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“…The olfactory epithelia (OE) and the olfactory bulb (OB) develop from the olfactory placode and the telencephalon, respectively (Fritzsch and Elliott, 2022;Imai, 2022). The olfactory placode is one of the cranial sensory placodes that give rise to several specialized sensory organs [OE, auditory and vestibular organs (Moody and LaMantia, 2015;Schlosser, 2021)].…”

Section: The Olfactory System Is Prominent In Vertebrates But Less De...mentioning

confidence: 99%

Gene networks and the evolution of olfactory organs, eyes, hair cells and motoneurons: a view encompassing lancelets, tunicates and vertebrates

Fritzsch,

Glover

2024

Front. Cell Dev. Biol.

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Key developmental pathways and gene networks underlie the formation of sensory cell types and structures involved in chemosensation, vision and mechanosensation, and of the efferents these sensory inputs can activate. We describe similarities and differences in these pathways and gene networks in selected species of the three main chordate groups, lancelets, tunicates, and vertebrates, leading to divergent development of olfactory receptors, eyes, hair cells and motoneurons. The lack of appropriately posited expression of certain transcription factors in lancelets and tunicates prevents them from developing vertebrate-like olfactory receptors and eyes, although they generate alternative structures for chemosensation and vision. Lancelets and tunicates lack mechanosensory cells associated with the sensation of acoustic stimuli, but have gravisensitive organs and ciliated epidermal sensory cells that may (and in some cases clearly do) provide mechanosensation and thus the capacity to respond to movement relative to surrounding water. Although functionally analogous to the vertebrate vestibular apparatus and lateral line, homology is questionable due to differences in the expression of the key transcription factors Neurog and Atoh1/7, on which development of vertebrate hair cells depends. The vertebrate hair cell-bearing inner ear and lateral line thus likely represent major evolutionary advances specific to vertebrates. Motoneurons develop in vertebrates under the control of the ventral signaling molecule hedgehog/sonic hedgehog (Hh,Shh), against an opposing inhibitory effect mediated by dorsal signaling molecules. Many elements of Shh-signaling and downstream genes involved in specifying and differentiating motoneurons are also exhibited by lancelets and tunicates, but the repertoire of MNs in vertebrates is broader, indicating greater diversity in motoneuron differentiation programs.

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Evolution of Neurosensory Cells and Systems

Cited by 2 publications

References 201 publications

Cross‐species analysis and comparison of the inner ear between chickens and mice

Cross‐species analysis and comparison of the inner ear between chickens and mice

Gene networks and the evolution of olfactory organs, eyes, hair cells and motoneurons: a view encompassing lancelets, tunicates and vertebrates

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