Evolution of precancerous laryngeal lesions: A clinicopathologic study with long-term follow-up on 259 patients

Gallo, Andrea; Vincentiis, Marco de; Rocca, Carlo Della; Moi, Rossana; Simonelli, Marilia; Minni, Antonio; Shaha, Ashok R.

doi:10.1002/1097-0347(200101)23:1<42::aid-hed7>3.0.co;2-1

Cited by 59 publications

(65 citation statements)

References 20 publications

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“…In addition, the present study identified advanced age as a risk factor for the diagnosis of laryngeal carcinoma in patients with vocal cord leukoplakia. This may be easily explained by the latency of progression from precancerous lesions to invasive cancer, and is consistent with the findings of previous studies (8,27).…”

Section: Discussionsupporting

confidence: 92%

Association of laryngeal cancer with vocal cord leukoplakia and associated risk factors in 1,184 patients diagnosed in otorhinolaryngology practices in Germany

Kostev¹,

Jacob

Kalder

et al. 2018

mol clin onc

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Abstract. The aim of the present study was to analyze the association between laryngeal cancer and vocal cord leukoplakia in a large nationwide practice database. The study sample included 1,184 patients aged 18-90 years from 113 otorhinolaryngology practices in Germany who were diagnosed with vocal cord leukoplakia between 2007 and 2014. The rates of laryngeal cancer diagnosis within 5 years and the associated risk factors were analyzed. Within 6 months of initial diagnosis of vocal cord leukoplakia, 11% of the patients were diagnosed with laryngeal cancer. Between 7 months and 5 years after the diagnosis of leukoplakia, laryngeal cancer was diagnosed in 7.6% of the patients. Overall, within 5 years of leukoplakia diagnosis, 18.6% of the patients were diagnosed with laryngeal cancer (26.1% of men and 6.3% of women; P<0.001). Moreover, 31.3% of patients aged >65 years, 16.1% of patients aged 50-65 years and 7.6% of patients aged <50 years were diagnosed with laryngeal cancer (P<0.001). Patients aged >65 and those aged 50-65 years had a higher risk of being diagnosed with laryngeal cancer [odds ratio (OR)=4.90 and 2.55, respectively]. Furthermore, the risk of being diagnosed with laryngeal cancer was higher in men compared with that in women (OR=4.09). In the present real-world analysis, the rate of laryngeal cancer underlying vocal cord leukoplakia at first diagnosis appeared to be higher compared with the secondary malignant transformation rate occurring later during the course of the disease. Risk factors for laryngeal cancer included advanced age and male sex.

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Section: Discussionsupporting

confidence: 92%

Association of laryngeal cancer with vocal cord leukoplakia and associated risk factors in 1,184 patients diagnosed in otorhinolaryngology practices in Germany

Kostev¹,

Jacob

Kalder

et al. 2018

mol clin onc

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“…Particular attention has been directed to the analysis of the interrelationship between histological parameters and their biological behaviour (Gale et al 2005, Gale et al 2006Kambicˇ&Gale, 1986;Putney&O'Keefe 1953;Kambicˇ 1978;Crissman 1979;Henry 1979;Hellquist et al, 1982;Gillis et al, 1983;Grundmann 1983;Goodman 1984;Crissman&Fu 1986;Velasco et al 1987;Olde-Kalter et al 1987;Crissman&Zarbo 1989;Sllamniku et al 1989;Bouquot et al, 1991a;Kambic&Gale 1995;Hellquist et al 1999;Gallo et al 2001;Ricci et al 2003). These analyses have been recently further supplemented by molecular genetic investigations trying to include the molecular events involved in the pathogenesis of oral squamous cell carcinoma (OSCC) to improve the prognostic evaluation of OIN (Ha&Califano 2002;Somers et al 1992;Saglam et al 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Common agreement has recently been achieved for terms that are used only for the clinical appearance and do not have any histopathological and prognostic implications. The most frequently applied clinical diagnoses are oral leukoplakia and erythroplakia (Kambicˇ&Gale 1995;Gallo et al 2001). In contrast, keratosis remains a controversial term, since it is often wrongly applied interchangeably to macroscopic and microscopic features, whereas it really represents a histological term denoting the appearance of a keratin layer on the surface of the squamous epithelium.…”

Section: Introductionmentioning

confidence: 99%

Novel Markers for Diagnosis and Prognosis of Oral Intraepithelial Neoplasia

Celetti¹,

Merolla²,

Luise³

et al. 2012

Intraepithelial Neoplasia

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“…[1][2][3][4] It is believed that squamous cell carcinoma (SCC), which comprises >90% of laryngeal malignancies, progresses through a series of well defined clinical and histopathologic stages in the form of precursor lesions with various degrees of dysplasia. [5][6][7] Clinically, these lesions appear mainly along the true vocal cord as white exophytic or shallow patches (leukoplakia). 8 The clinical appearance, however, is not reliably diagnostic of the histologic grade, and histopathologic examination is essential for the diagnosis.…”

mentioning

confidence: 99%

“…7 Moreover, because >50% of reported leukoplakia lesions reveal no dysplasia on biopsy, these patients are subjected to unnecessary surgical procedures. 6,7 Certain prediction of malignancy in laryngeal lesions can be achieved with the aid of new technologies, such as videostroboscopy, contact endoscopy, fluorescence endoscopy, high-frequency ultrasound, and optical coherence tomography, however; these techniques are not qualified to completely assess epithelial alterations, and biopsy is always needed. 9 Exfoliative cytology, although it is an established procedure in the diagnosis of carcinoma of the cervix and bronchus, has not been practiced to the same extent in premalignant laryngeal lesions.…”

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confidence: 99%

Noninvasive detection of aneuploid cells in laryngeal epithelial precursor lesions

Shani

Primov-Fever

Wolf

et al. 2011

Cancer Cytopathology

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BACKGROUND:Most cases of laryngeal cancer are preceded by precursor lesions which, if left untreated, can progress toward an invasive cancer. The objective of this study was to investigate the presence of chromosomal numerical aberrations in cells that were collected by noninvasive brush sampling from laryngeal lesions.METHODS:Laryngeal brush samples from 52 patients were analyzed simultaneously for morphology and fluorescence in situ hybridization (FISH) using centromeric probes for chromosome 17, chromosome 8, and a locus‐specific instability (LSI) v‐myc avian myelocytomatosis viral oncogene homolog (myc) proto‐oncogene protein (C‐MYC) probe for the MYC gene. The patients were divided according to histopathologic diagnosis. Group 1 included patients with squamous cell carcinoma, carcinoma in situ, and severe dysplasia; Group 2 included patients with moderate dysplasia, mild dysplasia, and hyperplasia; and Group 3 included patients with benign nondysplastic lesions.RESULTS:The proportion of cells with MYC and chromosome 8 gains demonstrated significant trends toward being the highest in Group 1 and the lowest in Group 3 (P = .001 and P = .003, respectively). No significant trend was observed for chromosome 17. Mann‐Whitney Bonferroni‐corrected analyses revealed that the most significant contribution was the difference between Groups 1 and 3 (P = .0195 for MYC gains and P = .036 for chromosome 8 gains). When using a cutoff point of 4% aneuploid cells (ACs), both MYC and chromosome 8 differed significantly between groups (P = .030 and P = .037, respectively).CONCLUSIONS:The current results suggested that FISH analysis of brush samples obtained noninvasively from suspicious laryngeal lesions can augment the clinical examination in predicting the nature of the lesions and can aid clinicians in monitoring and follow‐up of high‐risk patients. Cancer (Cancer Cytopathol) 2011. © 2011 American Cancer Society.

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Evolution of precancerous laryngeal lesions: A clinicopathologic study with long-term follow-up on 259 patients

Cited by 59 publications

References 20 publications

Association of laryngeal cancer with vocal cord leukoplakia and associated risk factors in 1,184 patients diagnosed in otorhinolaryngology practices in Germany

Association of laryngeal cancer with vocal cord leukoplakia and associated risk factors in 1,184 patients diagnosed in otorhinolaryngology practices in Germany

Novel Markers for Diagnosis and Prognosis of Oral Intraepithelial Neoplasia

Noninvasive detection of aneuploid cells in laryngeal epithelial precursor lesions

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