Evolution of Pregnancies and Initial Follow-up of Newborns Delivered after Intracytoplasmic Sperm Injection

Palermo, Gianpiero D.; Neri, Q.V.; Raffaelli, R.; Davis, Owen K.; Rosenwaks, Zev

doi:10.1007/978-3-642-58341-4_16

Cited by 16 publications

(19 citation statements)

References 47 publications

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“…33 Intracytoplasmic sperm injection represents an effective treatment for severe male factor infertility such as that observed in patients with CATSPER mutations and is now a routine procedure compatible with normal embryonic development. 34 There are conflicting reports on the risk of congenital birth defects associated with ICSI. A relatively low (4.2%) increased risk of congenital abnormalities for children conceived using ICSI has been reported in the largest multicenter study.…”

Section: Resultsmentioning

confidence: 99%

Genetic male infertility and mutation of CATSPER ion channels

et al. 2010

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Section: Resultsmentioning

confidence: 99%

Genetic male infertility and mutation of CATSPER ion channels

et al. 2010

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“…Earlier studies did not fi nd a rise in the malformation rate after ICSI [10,11,30,38,40] . However, the number of cases was either very low or there was no control group or the investigation technique was not performed in a standard fashion.…”

Section: Fetal Malformations After Artmentioning

confidence: 87%

Perinatal risks after IVF and ICSI

Zollner

Dietl

2012

Journal of Perinatal Medicine

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Pregnancies that occur after infertility treatment, particularly after assisted reproduction, constitute high-risk pregnancies. Occurrences of conditions such as high blood pressure, preeclampsia, growth retardations and bleeding are higher in comparison with the norm of spontaneously entered pregnancies. The rate of premature births and the frequency of intrauterine deaths are much higher than the average for all pregnancies. Furthermore, pregnancies resulting from in -vitro fertilisation (IVF) have signifi cantly higher rates of requiring induced labour or caesarean section. However, it is to be assumed that these complications and unfortunate developments are not caused by extracorporeal fertilisation itself, but rather are due to the frequency of multiples and to the risk factors of the women involved. These women are, on average, older and there are often more problems with cycle irregularities, uterine anomalies and obesity than in the total collective of all pregnancies. The methods of modern reproductive medicine often bring a higher rate of multiple pregnancies. The clinical problem of multiple pregnancies is, above all, the raised rate of premature births and intrauterine growth retardations that contribute to the signifi cantly higher rate of morbidity and mortality for these children. The slightly higher rate of congenital defects after IVF and intracytoplasmic sperm injection (ICSI) are also attributed more to the risk profi le of the parents and less to the techniques themselves. The most important and easy-to-avoid complication is the multiple pregnancy, and it should be our goal to lower this rate even further.

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“…We included all such studies. This probably did not affect our results as others have shown that the outcome as to MM is the same whether cryopreserved or fresh embryos are used (4)(5)(6). The process of selecting the 19 studies that met our inclusion criteria is shown in Fig.…”

Section: Methodsmentioning

confidence: 99%

A Meta-Analysis of Controlled Studies Comparing Major Malformation Rates in IVF and ICSI Infants with Naturally Conceived Children

Rimm

Katayama²,

Diaz

et al. 2004

J Assist Reprod Genet

251

120

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Purpose : To estimate the risk of major malformations in IVF and ICSI infants. Methods : Forty-four studies published in English since 1990 where the major malformation rate for IVF or ICSI cases was compared to an appropriate control group were reviewed. Nineteen studies met all selection criteria. In addition, a quality score was developed to assess each study based on sample size, timing of diagnosis, appropriateness of control group and other factors. Results : In 19 studies, the major malformation rates ranged from 0-9.5% for IVF; 1.1-9.7 for ICSI; and 0-6.9% in the control groups. When ICSI was compared to IVF, and multiple births compared to singleton, there were no statistically significant differences. When data from 16 studies involving 28,524 IVF infants and 2,520,988 spontaneously conceived controls and 7 studies involving 7234 ICSI infants and 978,078 controls were pooled, we found an overall odds ratio for the 19 studies of 1.29 (95% CI 1.01-1.67). Conclusions : The overall odds ratio of 1.29 was statistically significant at the 5% level. These results may be useful for counseling ART patients and properly designing the consent forms used for ART procedures. It is not clear whether this risk is due to the procedures used in ART. We found that some of these studies have design flaws. All of them lacked an appropriate control group, i.e. infertile patients conceiving spontaneously. These flaws may create biases that would in almost all instances increase the risk of major malformations in the study group. Further research with better designed studies will likely result in a better estimate of the risk of major malformations associated with IVF and ICSI.KEY WORDS: ART major malformation rate; IVF/ICSI major malformation rate; meta-analysis.

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Evolution of Pregnancies and Initial Follow-up of Newborns Delivered after Intracytoplasmic Sperm Injection

Cited by 16 publications

References 47 publications

Genetic male infertility and mutation of CATSPER ion channels

Genetic male infertility and mutation of CATSPER ion channels

Perinatal risks after IVF and ICSI

A Meta-Analysis of Controlled Studies Comparing Major Malformation Rates in IVF and ICSI Infants with Naturally Conceived Children

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