Evolution of renal function in living renal donors, five-year follow-up of patients operated in the same institution

Abstract

Introduction: Chronic kidney disease (CKD) has become a pathology with an increase in its prevalence during the last years. Renal transplantation offers a greater survival advantage for patients with end-stage renal disease. Main long-term conditions for kidney donors, as well as their renal function and the development of renal failure is yet to be studied. Methods: Cross-sectional, analytical study from January 1, 2005 to December 31, 2012 of living renal donors who participated in the renal transplant program of the Centro Médico Nacional de Occidente of the Instituto Mexicano del Seguro Social who were > 18 years of age and who complied with follow-up for 5 years. Results: 302 living donor nephrectomies were performed, a total of 78 patients were included. The estimated mean baseline glomerular filtration rate (GFR) measured in 24-hour urine prior to donation was 120.7 ± 25.82 ml/min/1.73m2, showing a considerable decrease in the first 3 months with an average of 77.9 ± 17.58 ml/min/1.73m2 which represents a decrease of 35.4% with respect to baseline. Conclusions: There is a significant decrease in renal function in living donors during the first months after nephrectomy, but this improves with evolution, although without returning to pre-donation levels.