Evolution of serum biochemical indicators in anorexia nervosa patients: a 1‐year follow‐up study

Nova, Esther; López‐Vidriero, Irene; Varela, Pilar; Casas, J.; Marcos, Ascensión

doi:10.1111/j.1365-277x.2007.00833.x

Cited by 23 publications

(29 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…41 Other proposed uses of Arg include also improvement of cardiovascular circulation and renal blood flow. 42 In addition, as hypercholesterolaemia is a common finding in patients with AN, [43][44][45][46] in line with our work, the abnormal lipid profile (increased total cholesterol and LDL-cholesterol levels) is associated with an elevated risk for arteriosclerotic diseases, 46 and in this regards Arg supplementation might be an useful tool in vascular health.…”

Section: Discussionsupporting

confidence: 85%

Anorexia nervosa: A role for L‐arginine supplementation in cardiovascular risk factors?

Vignini

D'Angelo

Nanetti

et al. 2009

Intl J Eating Disorders

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 85%

Anorexia nervosa: A role for L‐arginine supplementation in cardiovascular risk factors?

Vignini

D'Angelo

Nanetti

et al. 2009

Intl J Eating Disorders

View full text Add to dashboard Cite

show abstract

“…Some authors also showed that T-chol, HDL-chol, and LDLchol were higher in AN patients than in healthy subjects as indicators of severe malnourishment (28,29). On the other hand, Nova et al (30) reported that AST was significantly lower in AN patients compared with healthy subjects. However, the AST value was within the normal range in the present study because of the possible adaptive mechanisms that preserve liver function until advanced stages of debilitation such as seen in AN patients (31).…”

Section: Discussionmentioning

confidence: 93%

Characteristics of Body Composition and Resting Energy Expenditure in Lean Young Women

Hasegawa

Usui

Kawano

et al. 2011

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

SummaryThe number of lean young women has been increasing. Fear of being fat may induce unnecessary attempts to reduce body weight, which can cause several types of illness. Many investigations have demonstrated dysfunction of the hypothalamus and metabolic differences in patients with anorexia nervosa. However, it is unclear whether there are any differences in physical characteristics between women with lower body weight and no illness compared to those of normal body weight. In this study, we investigated the differences in body composition, biochemical parameters, and resting energy expenditure (REE) between young women with low and normal body mass index (BMI). Twenty lean women (BMI Ͻ 18.5 kg/m 2 ) and 20 normal women (18.5 Ϲ BMI Ͻ 25 kg/m 2 ) were recruited for this study. Body composition, biochemical parameters, and REE (REEm: measurement of REE) were measured, and the REE (REEe: estimation of REE) was estimated by using a prediction model. Marked differences were found in body composition. All of the values of blood analysis were in the normal ranges in both groups. REEm (kcal/d and kcal/kg BW/d) was significantly lower in lean than in normal women, but there were no significant differences in the REEm to fat free mass (FFM) ratio between the two groups. In addition, there was good agreement between REEm and REEe obtained from the specific metabolic rates of four tissue organs. These data indicate that the lean women without any illness have normal values of biochemical parameters and energy metabolism compared to women with normal BMI. Key Words lean women, body mass index, body composition, resting energy expenditureThe National Health and Nutritional Examination Survey of Japan in 2008 indicated that the number of lean women aged 20-30 y has been increasing. The ideal body mass index (BMI) is also lower in the young women compared to age matched men and even to women in other age groups. In fact, Takimoto et al.( 1 ) reported that the BMI, collected every 10 y between 1976 and 2000, has been decreasing among women between 20 and 30 y old. In addition, recent studies indicated that many young Japanese women overestimate their current BMI and express a their desire to lose weight ( 1 , 2 ). Fear of being fat may induce unnecessary attempts to reduce body weight ( 3 ). Going on a crash diet to lose weight causes illness and health incidents. In some cases, attempts to become thin are associated with nutritional deficiencies, irregular menstruation, osteoporosis and decreased resting energy expenditure (REE) ( 4-7 ). Moreover, previous studies suggested that low pre-pregnancy BMI and gestational weight gain are associated with low birth weight ( 8 , 9 ). Therefore, extreme weight loss may have an impact on not only the women themselves but also on their children. Many investigations indicated a dysfunction of hypothalamus and metabolic changes in patients with anorexia nervosa (AN) associated with excessive weight loss. Most AN patients have low level of estradiol and show amenorrhea or irregular menstr...

show abstract

“…Studies reveal conflicting results, with some studies showing elevations of AST and others showing low levels of AST 40,41 Both may be possible. An increase of AST is seen in any condition involving necrosis of hepatocytes, myocardial cells, or skeletal muscle cells.…”

Section: Liver Enzymesmentioning

confidence: 95%

Laboratory Parameters and Appetite Regulators in Patients with Anorexia Nervosa

Himmerich

Schönknecht²,

Heitmann³

et al. 2010

Journal of Psychiatric Practice

View full text Add to dashboard Cite

Anorexia nervosa (AN) has serious negative effects on multiple organs and systems of the human body. As patients often do not make their eating disorder the subject of discussion, the physician is forced to rely on the physical examination and laboratory parameters as diagnostic hints. Obvious signs of AN are a body mass index (BMI) below 17.5 kg/m, dry and scaly skin, lanugo, edema, acrocyanosis, petechias, dental problems, and low blood pressure. However, because the often complex laboratory alterations can be difficult for the general psychiatrist to interpret, this article presents some useful guidelines. The plasma of patients with AN often shows alterations in laboratory parameters and appetite regulators, including electrolytes, liver enzymes, leukocyte count, hemoglobin (Hb), leptin, neuropeptide Y (NPY), triiodothyronine (T3), follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrogen, ghrelin, pancreatic polypeptide (PP), tumor necrosis factor-alpha (TNF-alpha), and cortisol. Medical problems secondary to AN or due to the treatment itself may lead to further laboratory abnormalities. To date, despite these associated laboratory alterations, the diagnosis of anorexia is a clinical one, based on weight and specific psychopathology.

show abstract

Evolution of serum biochemical indicators in anorexia nervosa patients: a 1‐year follow‐up study

Abstract: Background Long-term studies on the evolution of serum biochemical indicators in anorexia nervosa (AN) patients during treatment are lacking in the literature. Thus, a 1-year follow-up of serum biochemical parameters in a homogeneous group of AN patients was performed.

Cited by 23 publications

References 19 publications

Anorexia nervosa: A role for L‐arginine supplementation in cardiovascular risk factors?

Anorexia nervosa: A role for L‐arginine supplementation in cardiovascular risk factors?

Characteristics of Body Composition and Resting Energy Expenditure in Lean Young Women

Laboratory Parameters and Appetite Regulators in Patients with Anorexia Nervosa

Contact Info

Product

Resources

About