Evolution of sinonasal clinical features in children with cystic fibrosis

Suy, Paul; Coudert, Aurélie; Vrielynck, S.; Truy, Éric; Hermann, R.; Ayari-Khalfallah, S.

doi:10.1016/j.ijporl.2019.05.030

Cited by 6 publications

(2 citation statements)

References 22 publications

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“…The most striking finding was the resolution of polyps in most participants. In childhood, polyps increase in size over time without surgical intervention, so the finding is unlikely to be due to chance [4] . In many cases, we saw very minor residual polypoid tissue in the prior location of large polyps that appeared shrunken or deflated.…”

Section: Elx/tez/iva Improves Radiologic Sinus Disease In Cfmentioning

confidence: 99%

“…Anosmia, chronic congestion, nasal obstruction, chronic rhinorrhea, and facial pain are all frequent symptoms of CF-CRS [3] . Symptoms can start to manifest in young children under the age of 5 years [4] and may require aggressive medical and surgical management, including repeated sinus surgeries [ 5 , 6 ]. Sinonasal quality of life scores, as well as general health related quality of life scores, are lower in patients with moderate to severe CF-CRS [7] , and CRS adds to the daily burden of medical care and maintenance therapy [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Elexacaftor-Tezacaftor- Ivacaftor improves sinonasal outcomes in cystic fibrosis

Stapleton

Kimple²,

Goralski³

et al. 2022

Journal of Cystic Fibrosis

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Section: Elx/tez/iva Improves Radiologic Sinus Disease In Cfmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Elexacaftor-Tezacaftor- Ivacaftor improves sinonasal outcomes in cystic fibrosis

Stapleton

Kimple²,

Goralski³

et al. 2022

Journal of Cystic Fibrosis

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Evaluation of otorhinolaryngologic, audiologic, and genetic findings in children with cystic fibrosis: A tertiary care experience

Nayır Büyükşahin,

Yalcın,

Gökırmak

et al. 2024

Pediatric Pulmonology

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ObjectivesTo evaluate otorhinolaryngologic findings and the relationship between aminoglycoside (AG) exposure and hearing loss in paediatric patients with cystic fibrosis (cwCF). We also aimed to investigate the genetic predisposition to AG ototoxicity by screening for m.1555A>G mutations.MethodsCwCF who underwent otorhinolaryngologic and audiologic examinations were retrospectively included. Clinical characteristics, ear‐nose‐throat related symptoms, and a history of ototoxic drug exposure were recorded. m.1555A>G mutations were retrospectively screened among patients with audiologic evaluations.ResultsTwo hundred thirty‐four cwCF were included in this study with a median age of 10.7 (range, 6.8–14.2) years. Nasal obstruction (14.1%) was the most common symptom. Fifty‐two (22.2%) patients had chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP). There was a positive correlation between CRSwNP and the symptom of nasal obstruction (r:.234, p < .001), snoring (r:.179, p = .006), and sleeping with mouth open (r:.138, p = .034). One hundred forty‐nine (63.6%) patients had audiologic evaluations; 14 (9.4%) had hearing impairment. No statistical significance existed between ototoxicity and IV AG exposure (p = .90). Six (42.8%) of 14 patients did not receive ototoxic drugs. One hundred nineteen (50.8%) patients were screened for m.1555A>G mutations, and none were detected.ConclusionsAlmost a quarter of the study population had CRSwNP. Neither the relationship between AGs exposure and hearing loss nor the genetic predisposition to AG ototoxicity could be shown in cwCF.

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Differing rates of fungi in sinonasal cultures from pediatric sinusitis patients

Gitomer

Poore

Anand

et al. 2022

International Journal of Pediatric Otorhinolaryngology

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Evolution of sinonasal clinical features in children with cystic fibrosis

Cited by 6 publications

References 22 publications

Elexacaftor-Tezacaftor- Ivacaftor improves sinonasal outcomes in cystic fibrosis

Elexacaftor-Tezacaftor- Ivacaftor improves sinonasal outcomes in cystic fibrosis

Evaluation of otorhinolaryngologic, audiologic, and genetic findings in children with cystic fibrosis: A tertiary care experience

Differing rates of fungi in sinonasal cultures from pediatric sinusitis patients

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