2024
DOI: 10.1038/s41467-024-49758-0
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Evolution of STAT2 resistance to flavivirus NS5 occurred multiple times despite genetic constraints

Ethan C. Veit,
Madihah S. Salim,
Mariel J. Jung
et al.

Abstract: Zika and dengue virus nonstructural protein 5 antagonism of STAT2, a critical interferon signaling transcription factor, to suppress the host interferon response is required for viremia and pathogenesis in a vertebrate host. This affects viral species tropism, as mouse STAT2 resistance renders only immunocompromised or humanized STAT2 mice infectable. Here, we explore how STAT2 evolution impacts antagonism. By measuring the susceptibility of 38 diverse STAT2 proteins, we demonstrate that resistance arose numer… Show more

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