2019
DOI: 10.3389/fpls.2019.01523
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Evolution of Structural Diversity of Triterpenoids

Abstract: Plants have evolved to produce a blend of specialized metabolites that serve functional roles in plant adaptation. Among them, triterpenoids are one of the largest subclasses of such specialized metabolites, with more than 14,000 known structures. They play a role in plant defense and development and have potential applications within food and pharma. Triterpenoids are cyclized from oxidized squalene precursors by oxidosqualene cyclases, creating more than 100 different cyclical triterpene scaffolds. This limi… Show more

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Cited by 97 publications
(74 citation statements)
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“…Candidate genes underlying this cluster include two multidrug and toxin efflux (MATE) transporters, possibly involved in vacuolar sequestration of SGAs; a cytochrome P450 contributing to SGA biosynthesis in potato (Manrique-Carpintero et al, 2014); and a cluster of genes encoding possible beta-amyrin 28-monooxygenases, involved in a competing branch of triterpenoid biosynthesis (Daniel et al, 2017). A QTL for demissine in the flesh (F-DEM.5.1) contains a gene encoding a UGT94 enzyme (a tomato GAME18 homolog) (Cárdenas et al, 2019). Within the confidence interval of the major QTL on chr.…”
Section: Steroidal Glycoalkaloids (Sgas)mentioning
confidence: 99%
“…Candidate genes underlying this cluster include two multidrug and toxin efflux (MATE) transporters, possibly involved in vacuolar sequestration of SGAs; a cytochrome P450 contributing to SGA biosynthesis in potato (Manrique-Carpintero et al, 2014); and a cluster of genes encoding possible beta-amyrin 28-monooxygenases, involved in a competing branch of triterpenoid biosynthesis (Daniel et al, 2017). A QTL for demissine in the flesh (F-DEM.5.1) contains a gene encoding a UGT94 enzyme (a tomato GAME18 homolog) (Cárdenas et al, 2019). Within the confidence interval of the major QTL on chr.…”
Section: Steroidal Glycoalkaloids (Sgas)mentioning
confidence: 99%
“…Generally, the more types of metabolites, the more copy of genes are required. In different plants, there are big differences in the number of genes, like triterpenoids (Khakimov et al, 2015;Itkin et al, 2016;Erthmann et al, 2018;Cárdenas et al, 2019;Liu et al, 2019). Tandem repeat is the most important source in the formation of these genes.…”
Section: Tandem Repeats Of Ta Genes Indicated Their Evolutionary Originmentioning
confidence: 99%
“…To illustrate this heterogeneity, we focused on terpenes (including triterpenoids and diterpenoids). These are common plant-derived metabolites [19] that were readily annotatable in our dataset. Some triterpenoids were found uniquely in a given state (e.g., m/z 409.346, RT 7.56 min, annotated as echinocystic acid and found only in CA), while other triterpenoids are found in multiple states and regions (e.g., m/z 443.389, RT 8.30 min, annotated as uvaol and found in Central, Northeast, West and South regions (OK, PA, CA, TN)) ( Figure 3c).…”
Section: Specific Chemistries Identified In Backyard Soil Samplesmentioning
confidence: 99%