We have investigated Se substitution effect to superconductivity of an optimally-doped BiS 2 -based superconductor Eu 0.5 La 0.5 FBiS 2 . Eu 0.5 La 0.5 FBiS 2-x Se x samples with x = 0˗1 were synthesized. With increasing x, in-plane chemical pressure is enhanced. For x ≥ 0.6, superconducting transitions with a large shielding volume fraction are observed in magnetic susceptibility measurements, and the highest T c is 3.8 K for x = 0.8. From low-temperature electrical resistivity measurements, a zero-resistivity state is observed for all the samples, and the highest T c is observed for x = 0.8. With increasing Se concentration, characteristics of electrical resistivity changes from semiconducting-like to metallic, suggesting that the emergence of bulk superconductivity is linked with the enhanced metallicity. A superconductivity phase diagram of the Eu 0.5 La 0.5 FBiS 2-x Se x superconductor is established. Temperature dependences of electrical resistivity show an anomalous two-step transition under high magnetic fields. Hence, the resistivity data are analyzed with assuming in-plane anisotropy of upper critical field.