Evolution of Symptomatic Diffuse Esophageal Spasm to Achalasia

Gf, Longstreth; Foroozan, Parviz

doi:10.1097/00007611-198202000-00023

Cited by 14 publications

(6 citation statements)

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“…The pathophysiology proposed is, initially higher LES pressure (Hy LES), then gradual loss of peristaltic pattern (DES to AC). 26,28 Patients with DES and Hy LES had higher average amplitude of contractions in the esophageal body than the proximal esophagus.…”

Section: Discussionmentioning

confidence: 96%

Manometric and symptomatic spectrum of motor dysphagia in a tertiary referral center in northern India

Misra

Chourasia

Ghoshal

2010

Indian J Gastroenterol

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Section: Discussionmentioning

confidence: 96%

Manometric and symptomatic spectrum of motor dysphagia in a tertiary referral center in northern India

Misra

Chourasia

Ghoshal

2010

Indian J Gastroenterol

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“…Other studies with a small number of patients documented degeneration starting from 1 to 4 years of DES diagnosis. [4][5][6][7][8][9][10][11] Interestingly, gastroesophageal reflux disease was not excluded in these studies.…”

Section: Discussionmentioning

confidence: 99%

“…The transition of certain primary esophageal motor disorders into achalasia is unquestionably a possible event. The change of nutcracker esophagus to achalasia 1,2 and especially diffuse esophageal spasm (DES) to achalasia [3][4][5][6][7][8][9][10][11][12] have been documented. Most studies, however, are case reports, and the true incidence of these manometric changes is still elusive.…”

Section: Introductionmentioning

confidence: 99%

Progression of diffuse esophageal spasm to achalasia: incidence and predictive factors

Fontes

Herbella

Navarro–Rodriguez

et al. 2012

Diseases of the Esophagus

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SUMMARY The progression of certain primary esophageal motor disorders to achalasia has been documented; however, the true incidence of this decay is still elusive. This study aims to evaluate: (i) the incidence of the progression of diffuse esophageal spasm to achalasia, and (ii) predictive factors to this progression. Thirty‐five patients (mean age 53 years, 80% females) with a manometric picture of diffuse esophageal spasm were followed for at least 1 year. Patients with gastroesophageal reflux disease confirmed by pH monitoring or systemic diseases that may affect esophageal motility were excluded. Esophageal manometry was repeated in all patients. Five (14%) of the patients progressed to achalasia at a mean follow‐up of 2.1 (range 1–4) years. Demographic characteristics were not predictive of transition to achalasia, while dysphagia (P= 0.005) as the main symptom and the wave amplitude of simultaneous waves less than 50 mmHg (P= 0.003) were statistically significant. In conclusion, the transition of diffuse esophageal spasm to achalasia is not frequent at a 2‐year follow‐up. Dysphagia and simultaneous waves with low amplitude are predictive factors for this degeneration.

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“…Several reports describe the progression of DES to achalasia. [6][7][8] Khatami et al 10 conducted the first prospective cohort study with 12 patients. They observed the progression of DES to achalasia in only one patient after 10.6 years.…”

Section: Discussionmentioning

confidence: 99%

“…3 Several reports have described patients with diffuse esophageal spasm (DES), non-specific esophageal motor disorder (NSEMD), nutcracker esophagus, and gastroesophageal reflux disease (GERD) progressing to achalasia. [4][5][6][7][8][9] Although no causal relationship has been identified, these reports suggest that the different esophageal motor disorders represent a spectrum rather than unique and stable disorders. We describe, for the first time, a case of a patient who progressed from jackhammer esophagus to type II achalasia.…”

Section: Introductionmentioning

confidence: 99%

Progression of Jackhammer Esophagus to Type II Achalasia

Abdallah

Fass

2015

J Neurogastroenterol Motil

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It has been suggested that patients with certain motility disorders may progress overtime to develop achalasia. We describe a 66 year-old woman who presented with dysphagia for solids and liquids for a period of 18 months. Her initial workup showed normal endoscopy and non-specific esophageal motility disorder on conventional manometry. Six months later, due to persistence of symptoms, the patient underwent a high resolution esophageal manometry (HREM) demonstrating jackhammer esophagus. The patient was treated with a high dose proton pump inhibitor but without resolution of her symptoms. During the last year, the patient reported repeated episodes of food regurgitation and a significant weight loss. A repeat HREM revealed type II achalasia. Multiple case reports, and only a few prospective studies have demonstrated progression from certain esophageal motility disorders to achalasia. However, this report is the first to describe a case of jackhammer esophagus progressing to type II achalasia.

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Evolution of Symptomatic Diffuse Esophageal Spasm to Achalasia

Cited by 14 publications

References 0 publications

Manometric and symptomatic spectrum of motor dysphagia in a tertiary referral center in northern India

Manometric and symptomatic spectrum of motor dysphagia in a tertiary referral center in northern India

Progression of diffuse esophageal spasm to achalasia: incidence and predictive factors

Progression of Jackhammer Esophagus to Type II Achalasia

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