Evolution of the 2′-5′-Oligoadenylate Synthetase Family in Eukaryotes and Bacteria

Kjær, Karina Hansen; Poulsen, Jesper Buchhave; Reintamm, Tõnu; Saby, Emilie; Martensen, Pia M.; Kelve, Merike; Justesen, Just

doi:10.1007/s00239-009-9299-1

Cited by 48 publications

(36 citation statements)

References 35 publications

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“…OAS family proteins exhibit antiviral effects against various viruses (i.e. DENV, WNV, HCV and JEV) through RNase L-dependent and RIG-dependent (RNase Lindependent) signalling pathways [52,53]. A member of the OAS superfamily, only the OASL protein, but not the OAS protein, has been identified in birds [54][55][56].…”

Section: The Innate Immune Response To Avian Tmuv Infectionmentioning

confidence: 99%

An updated review of avian-origin Tembusu virus: a newly emerging avian Flavivirus

Zhang

Chen

Mahalingam

et al. 2017

Journal of General Virology

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Tembusu virus (TMUV, genus Flavivirus, family Flaviviridae) was first isolated in 1955 from Culex tritaeniorhynchus mosquitoes in Kuala Lumpur, Malaysia. In April 2010, duck TMUV was first identified as the causative agent of egg-drop syndrome, characterized by a substantial decrease in egg laying and depression, growth retardation and neurological signs or death in infected egg-laying and breeder ducks, in the People's Republic of China. Since 2010, duck TMUV has spread to most of the duck-producing regions in China, including many of the coastal provinces, neighbouring regions and certain Southeast Asia areas (i.e. Thailand and Malaysia). This review describes the current understanding of the genome characteristics, host range, transmission, epidemiology, phylogenetic and immune evasion of avian-origin TMUV and the innate immune response of the host.

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Section: The Innate Immune Response To Avian Tmuv Infectionmentioning

confidence: 99%

An updated review of avian-origin Tembusu virus: a newly emerging avian Flavivirus

Zhang

Chen

Mahalingam

et al. 2017

Journal of General Virology

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“…The European Food Safety Authority reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors. Molluscs have 2'5'-oligoadenylate synthetases (Kjaer et al, 2009;Pari et al, 2014), RIG-I-like protein , MDA5 (Green et al, 2014), and PKR (Green and Montagnani, 2013;Green et al, 2014;Green et al, 2015b). Poly I:C can be also bound by Leucine-rich repeat (LRR)-only protein found in scallop Chlamys farreri Wang et al, 2016c).…”

Section: Literature Review Of Baseline Information To Support the Rismentioning

confidence: 99%

“…protein involved in dsRNA response -OAS (Kjaer et al, 2009). We ?performed Blast search for murine PKR, RIG-I, and MDA5 (algorithm: tblastn, database: Nucleotide collection nr/nt, results restricted to Annelida (taxid:6340)).…”

Section: Other Dsrna Responding Pathwaysmentioning

confidence: 99%

Literature review of baseline information to support the risk assessment of RNAi‐based GM plants

Pačes

Nič²,

Novotný³

et al. 2017

EFS3

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This report is the outcome of an EFSA procurement aiming at investigating and summarising the state of knowledge on (I) the mode-of-action of dsRNA and miRNA pathways, (II) the potential for nontarget gene regulation by dsRNA-derived siRNAs or miRNAs, (III) the determination of siRNA pools in plant tissues and the importance of individual siRNAs for silencing. The report is based on a comprehensive and systematic literature search, starting with the identification and retrieval of~190,000 publications related to the research area and further filtered down with keywords to produce focused collections used for subsequent screening of titles and abstracts. The report is comprised of an (I) Introduction to the field of small RNAs, (II) a Data and Methodologies section containing strategies used for literature search and study selection, and (III) the Results of the literature review organized according to the three main procurement tasks. The outcome of the first task reviews dsRNA and miRNA pathways in mammals (including humans), birds, fish, arthropods, annelids, molluscs, nematodes, and plants. Eight taxon-dedicated chapters are based on~1,400 cumulative references chosen from~10,000 inspected titles and abstracts. We review conserved and divergent aspects of small RNA pathways and dsRNA responses in animals and plants including structure and function of key proteins as well as four basic mechanisms: genome-encoded posttranscriptional regulations (miRNA), degradation of RNAs by short interfering RNA pools generated from long dsRNA (RNAi), transcriptional silencing, and sequence-independent responses to dsRNA. The outcome of the second task focuses on base pairing between small RNAs and their target RNAs and predictability of biological effects of small RNAs in animals and plants. The outcome of the last task reviews methodology, siRNA pools, and movement of small RNAs in plants. Potential transfer of small RNAs between species and circulating miRNAs in mammals is described in the final chapter.

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“…Although it was initially believed that larger isoforms like OAS2 and OAS3 are only present in mammals, homologs of larger OAS enzymes have now been reported in primitive life forms like sponges and metazoan [219--221]. Interestingly fish, sharks and many insect varieties gave don't appear to contain OAS homologs [220].…”

Section: Enzyme Catalysis and Possible Oligomerization Requirement Fomentioning

confidence: 99%

Characterization of the termini of the West Nile virus genome and their interactions with the small isoform of the 2′ 5′-oligoadenylate synthetase family

Deo

Patel

Chojnowski

et al. 2015

Journal of Structural Biology

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confirmed the specificity of the interaction. Solution conformations of both the 5'--TR RNA of WNV and OAS1 were then elucidated using small--angle x--ray scattering. I also report that the 3' terminal region (3'--TR) is able to mediate specific interaction with and activation of OAS1. Binding and kinetic experiments identified a specific stem loop within the 3'--TR that is sufficient for activation of the enzyme. The solution confirmation of the 3'--terminal region was determined by small angle X--ray scattering, and computational models suggest a conformationally restrained structure comprised of a helix and short stem loop. Structural investigation of the 3'--ii TR in complex with OAS1 is also presented. Finally, we show that genome cyclization by base pairing between the 5'--and 3'--TRs, a required step for replication, is not sufficient to protect WNV from OAS1 recognition. The purity, monodispersity and homogeneity of all samples subjected to SAXS analysis were evaluated using dynamic light scattering and/or analytical ultra--centrifuge. These data provide a framework for understanding recognition of the highly structured terminal regions of a flaviviral genome by an innate immune enzyme.iii

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Evolution of the 2′-5′-Oligoadenylate Synthetase Family in Eukaryotes and Bacteria

Cited by 48 publications

References 35 publications

An updated review of avian-origin Tembusu virus: a newly emerging avian Flavivirus

An updated review of avian-origin Tembusu virus: a newly emerging avian Flavivirus

Literature review of baseline information to support the risk assessment of RNAi‐based GM plants

Characterization of the termini of the West Nile virus genome and their interactions with the small isoform of the 2′ 5′-oligoadenylate synthetase family

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