The objective of this study is to evaluate the impact of orientation on the thermal comfort of bioclimatic buildings in general, and in particular those built with compressed earth blocks. A first experimental study confirmed that compressed earth blocks have good thermal inertia, and made it possible to determine the number of annual hours of thermal comfort in the room. The results showed a thermal phase shift of 6 hours with a temperature difference of 10°C between the outside and the inside of the room, for an annual total of 4788 hours of comfort (54.65%) compared to 2158 hours of discomfort (49.80%), with a hygrothermal index (HIT) of 1.6 and an annual cooling requirement of 753.55 kWh. Subsequently, dynamic thermal simulations (DTS) carried out on different orientations made it possible to optimize the thermal comfort and energy consumption of the premises studied. The NORTHEAST and SOUTH-EAST orientation of the facades, with the two windows of the premises, made it possible to achieve 78.1% thermal comfort, or 6833 hours, a HIT of 0.5 and an annual power requirement of cooling of 523.78 kWh. Finally, similar work was carried out to propose optimal orientations for bioclimatic buildings in the three climatic zones of Burkina Faso.