Evolution of the design of Venturi devices for the delivery of dry particles to skin or mucosal tissue

Costigan, George P.; Liu, Y.; Brown, G. T.; Carter, F. V.; Bellhouse, B. J.

doi:10.1007/978-3-540-27009-6_107

Cited by 7 publications

(9 citation statements)

References 2 publications

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“…The Venturi device has been developed and intensively investigated experimentally and analytically [7]. MIFVS calculations are performed here in an attempt to gain some insights into the ow characteristics of the Venturi system, to provide some fundamental understanding and optimize the aerodynamic design.…”

Section: Venturi Powder Injection Systemmentioning

confidence: 99%

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Prediction of jet flows in the supersonic nozzle and diffuser

Liu

Bellhouse

2005

Numerical Methods in Fluids

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SUMMARYThe authors' recently-developed code for a needle-free powdered vaccine delivery device, the epidermal powdered inject system (EPI), is summarized in this paper. The behaviour of supersonic jet ows, which accelerate micron sized powdered vaccines to penetrate human skin or mucosal tissue, is therefore of great importance. A well-established modiÿed implicit ux vector splitting (MIFVS) solver for the Navier-Stokes equations is extended to study numerically the transient supersonic jet ows of interest. A low Reynolds number k-turbulence model, with the compressibility e ect considered, is integrated into MIFVS solver to predict the turbulent structures and interactions with inherent shock systems. The results for the NASA validation case NPARC, Venturi and contoured shock tube (CST) of the EPI system are discussed.

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Section: Venturi Powder Injection Systemmentioning

confidence: 99%

“…This code is then applied to prototypes of the EPI system based on the Venturi principle (Venturi [7]) and a contoured shock tube (CST [8,9]), respectively.…”

Section: Validationmentioning

confidence: 99%

Prediction of jet flows in the supersonic nozzle and diffuser

Liu

Bellhouse

2005

Numerical Methods in Fluids

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“…Both alum and K-Hap conditions showed significantly higher mean GMTs than the naive control (P Ͻ 0.001). An approximately 1.4-fold increase in IgG GMT levels was observed for K-Hap-CRM 197 , and a 1.7-fold increase in the alum-adjuvanted CRM 197 condition was seen between days 28 sentation of CRM 197 in the K-Hap microparticle surface-adsorbed state could influence the IgG1/IgG2a balance. The alum-adjuvanted and needle-free K-Hap groups both showed a 2-fold IgG1/ IgG2a-biased response.…”

Section: Resultsmentioning

confidence: 89%

“…Here, we investigate whether intradermal delivery of Hap microparticles can elicit antibody titers to the adsorbed CRM 197 protein antigen, using the Venturi needle-free ballistic injection device (28). The diphtheria toxin mutant CRM 197 protein is a 58-kDa, two-subunit, nontoxic protein that is frequently used as a polysaccharide carrier protein in commercial glycoconjugate vaccines, but it is poorly immunogenic without adjuvantation (29)(30)(31).…”

mentioning

confidence: 99%

Needle-Free Dermal Delivery of a Diphtheria Toxin CRM₁₉₇Mutant on Potassium-Doped Hydroxyapatite Microparticles

Weissmueller

Schiffter

Carlisle

et al. 2015

Clin. Vaccine Immunol.

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cInjections with a hypodermic needle and syringe (HNS) are the current standard of care globally, but the use of needles is not without limitation. While a plethora of needle-free injection devices exist, vaccine reformulation is costly and presents a barrier to their widespread clinical application. To provide a simple, needle-free, and broad-spectrum protein antigen delivery platform, we developed novel potassium-doped hydroxyapatite (K-Hap) microparticles with improved protein loading capabilities that can provide sustained local antigen presentation and release. K-Hap showed increased protein adsorption over regular hydroxyapatite (P < 0.001), good structural retention of the model antigen (CRM 197 ) with 1% decrease in ␣-helix content and no change in ␤-sheet content upon adsorption, and sustained release in vitro. Needle-free intradermal powder inoculation with K-Hap-CRM 197 induced significantly higher IgG1 geometric mean titers (GMTs) than IgG2a GMTs in a BALB/c mouse model (P < 0.001) and induced IgG titer levels that were not different from the current clinical standard (P > 0.05), namely, alum-adsorbed CRM 197 by intramuscular (i.m.) delivery. The presented results suggest that K-Hap microparticles may be used as a novel needlefree delivery vehicle for some protein antigens.T he number of immunizations rises annually with population growth, vaccine availability, and sophistication of immunization schedules. Consequently, the risk associated with needles as a vector of infection is contributing to the global burden of disease (1-3). Of the 16 billion therapeutic injections administered with needles and syringes in 2004 globally, 800 million were prophylactic inoculations, and approximately 30 million of the 16 billion (or 0.19%) resulted in needlestick injuries, some of which have transmitted blood-borne pathogens, such as HIV, hepatitis B, or hepatitis C (4, 5).While a plethora of needle-free inoculation devices exists, most needle-free immunization technologies require the reformulation of vaccines that are routinely administered with a hypodermic needle and syringe (HNS) (6-8). In the case of protein antigens, dry-powder manufacture for intradermal or mucosal delivery is largely empirical and hence particularly costly, which presents a barrier to the widespread use of needle-free inoculation (9-13).Protein antigens are often poorly immunogenic and generally require the addition of an adjuvant to elicit robust antibody responses (14, 15). Colloidal adjuvants, such as aluminum salts, are routinely used to boost vaccine immunogenicity (16). However, previous efforts to reformulate vaccines for use in needle-free intradermal injection have linked aluminum salt coformulation with an increased aggregate content and the denaturation of the protein antigen after lyophilization or spray lyophilization (17-21). Furthermore, alum has been reported to induce granuloma formation when injected intradermally (22). While alum adjuvantation is problematic in combination with lyophilization and dermal inoculation, a...

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“…To provide an alternative mode of vaccine introduction, a membrane-free device, called the venturi DNA vaccine delivery system (venturi) has been developed [23,24]. Earlier studies with an experimental venturi device suggested that particles were delivered with a wide range of velocity and spatial distributions.…”

Section: Introductionmentioning

confidence: 99%

Utilization of the venturi effect to introduce micro-particles for epidermal vaccination

Liu

2007

Medical Engineering & Physics

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Evolution of the design of Venturi devices for the delivery of dry particles to skin or mucosal tissue

Cited by 7 publications

References 2 publications

Prediction of jet flows in the supersonic nozzle and diffuser

Prediction of jet flows in the supersonic nozzle and diffuser

Needle-Free Dermal Delivery of a Diphtheria Toxin CRM₁₉₇Mutant on Potassium-Doped Hydroxyapatite Microparticles

Utilization of the venturi effect to introduce micro-particles for epidermal vaccination

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Evolution of the design of Venturi devices for the delivery of dry particles to skin or mucosal tissue

Cited by 7 publications

References 2 publications

Prediction of jet flows in the supersonic nozzle and diffuser

Prediction of jet flows in the supersonic nozzle and diffuser

Needle-Free Dermal Delivery of a Diphtheria Toxin CRM197Mutant on Potassium-Doped Hydroxyapatite Microparticles

Utilization of the venturi effect to introduce micro-particles for epidermal vaccination

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Needle-Free Dermal Delivery of a Diphtheria Toxin CRM₁₉₇Mutant on Potassium-Doped Hydroxyapatite Microparticles