Drawing upon both classic and more contemporary world-systems analysis, along with oft-forgotten sections of Arghiri Emmanuel’s work on technology, this paper studies, through a quantitative and qualitative comparative method, the history and development of the global semiconductors industry, its selective spatial re-organization/peripheralization over time, and the logic of technology transfers within the context of core-monopolization of high profit industries. The paper then draws comparisons between semiconductors and prior core-monopolized industries like the automobile industry, and analyzes attempts at entry into core-like production by the large semi-peripheries such as China and India and the difficulties faced by them not only by the structural limitations of the world-system but also due to opposition from the core nations (like the U.S.-China Trade War). Resultingly, the analysis concludes that significant upward mobility for the large semi-peripheries through entry into core industries is, within the current capitalist world-system, largely unfeasible.