2020
DOI: 10.3390/genes11040383
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Evolution of the Human Chromosome 13 Synteny: Evolutionary Rearrangements, Plasticity, Human Disease Genes and Cancer Breakpoints

Abstract: The history of each human chromosome can be studied through comparative cytogenetic approaches in mammals which permit the identification of human chromosomal homologies and rearrangements between species. Comparative banding, chromosome painting, Bacterial Artificial Chromosome (BAC) mapping and genome data permit researchers to formulate hypotheses about ancestral chromosome forms. Human chromosome 13 has been previously shown to be conserved as a single syntenic element in the Ancestral Primate Karyotype; i… Show more

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Cited by 10 publications
(9 citation statements)
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“…Molecular cytogenetic studies by FISH with human probes permitted to show no interchromosomal rearrangements in representative species from Saguinus and Leontopithecus genera (Gerbault‐Serreau et al, 2004; Neusser et al, 2001). On the other hand, intrachromosomal rearrangements have been suggested in part by classic G banding (Nagamachi et al, 1997, 1999) and also by analyses of single locus or BAC probe mapping on tamarins (Dumas & Sineo, 2012, 2014; Dumas et al, 2015; Scardino, Milioto, et al, 2020); indeed inversions, as well as variations in the size and distribution of heterochromatic blocks, are the major cytogenetic differences among tamarin karyotypes.…”
Section: Introductionmentioning
confidence: 99%
“…Molecular cytogenetic studies by FISH with human probes permitted to show no interchromosomal rearrangements in representative species from Saguinus and Leontopithecus genera (Gerbault‐Serreau et al, 2004; Neusser et al, 2001). On the other hand, intrachromosomal rearrangements have been suggested in part by classic G banding (Nagamachi et al, 1997, 1999) and also by analyses of single locus or BAC probe mapping on tamarins (Dumas & Sineo, 2012, 2014; Dumas et al, 2015; Scardino, Milioto, et al, 2020); indeed inversions, as well as variations in the size and distribution of heterochromatic blocks, are the major cytogenetic differences among tamarin karyotypes.…”
Section: Introductionmentioning
confidence: 99%
“…Molecular cytogenetic methodologies were applied only recently to explore the karyotype evolution of emydid turtles, such as fluorescence in situ hybridization (FISH), with probes specific to the telomeric sequences (TTAGGG) n [22,[25][26][27] and the rDNA loci [20,27]. FISH is a technique that allows one to detect the presence and distribution of a sequence of interest directly on the chromosome metaphase of the studied species [28][29][30][31][32][33][34]. The comparative analysis of the in situ hybridization pattern, using a combination of probes specific for different genomic regions, can be informative for phylogenetic analysis [35,36].…”
Section: Introductionmentioning
confidence: 99%
“…[ 58 , 59 , 60 ]. The fluorescent in situ hybridization (FISH) method has a diverse utilization in a study of evolutionary processes due to many modifications focused on various types of targeted nucleotide sequences used as probes in various animal species [ 61 , 62 , 63 ]. The FISH method, in which rDNA probes are hybridized on chromosomal DNA, reveals exact chromosomal positions where the rDNAs are situated.…”
Section: Synergy Of Conventional Chromosome Banding and Ribosomal Flu...mentioning
confidence: 99%