Evolution of the Ion Channel Concept: The Historical Perspective

Behrends, Jan C.

doi:10.1021/cr300349g

Cited by 23 publications

(7 citation statements)

References 92 publications

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“…Vesicular transport of 'particles' was suggested in the 1950s (see below) and remains an attractive but controversial topic for discussion and research into transport processes in plants. Historically, the concept of vesicular ion transport was based on microscopic observations and preceded ideas about the existence of ion channels and transporters (Behrends, 2012). However, the rapid rise of research into membrane transport proteins and the intensive accumulation of knowledge of ion channels pushed ideas on vesicular ion transport into the shadows, virtually suppressing and abolishing them.…”

Section: Introductionmentioning

confidence: 99%

Could vesicular transport of Na+ and Cl– be a feature of salt tolerance in halophytes?

2018

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There is strong evidence in favour of vesicular transport in plants and circumstantial evidence in favour of the movement of ions in vesicles. Estimated rates of vesicle turnover could account for ion transport at the lower reported fluxes (around 20 nmol m-2 s-1), but the higher fluxes may require vesicles of the order of 1 μm or more in diameter. The very high fluxes reported in some salt glands might be an artefact of the way they were measured.

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Section: Introductionmentioning

confidence: 99%

Could vesicular transport of Na+ and Cl– be a feature of salt tolerance in halophytes?

2018

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“…The most convenient targets for analysis by electrochemical methods in pharmaceutical industry are ion channel proteins [ 244 ]. These proteins play essential roles in many cellular functions of human body, such as signal transmission in the nervous systems and mass transportation across the cell membrane [ 245 ]. A number of common diseases, such as epilepsy, arrhythmia, are found to be connected to ion channel dysfunctions [ 246 ].…”

Section: Application Of Msss and Msasmentioning

confidence: 99%

Multisensor Systems and Arrays for Medical Applications Employing Naturally-Occurring Compounds and Materials

Pauliukaitė

Voitechovič

2020

Sensors

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The significant improvement of quality of life achieved over the last decades has stimulated the development of new approaches in medicine to take into account the personal needs of each patient. Precision medicine, providing healthcare customization, opens new horizons in the diagnosis, treatment and prevention of numerous diseases. As a consequence, there is a growing demand for novel analytical devices and methods capable of addressing the challenges of precision medicine. For example, various types of sensors or their arrays are highly suitable for simultaneous monitoring of multiple analytes in complex biological media in order to obtain more information about the health status of a patient or to follow the treatment process. Besides, the development of sustainable sensors based on natural chemicals allows reducing their environmental impact. This review is concerned with the application of such analytical platforms in various areas of medicine: analysis of body fluids, wearable sensors, drug manufacturing and screening. The importance and role of naturally-occurring compounds in the development of electrochemical multisensor systems and arrays are discussed.

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“…Approximately 40 years ago, the existence of ion channels was controversial: They were not regarded as molecular entities, despite the evidence for pores from measurements of the electrical properties of the cell membrane. The concept of ion channels was developed to explain how biological membranes exhibit electrical conductance to selected ions and how this permeability is regulated and changed locally and rapidly by electrical, chemical or mechanical stimuli [4]. …”

Section: General Principles Of Ion Channelsmentioning

confidence: 99%

Structural and Molecular Modeling Features of P2X Receptors

Alves

Silva

Ferreira

et al. 2014

IJMS

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Currently, adenosine 5′-triphosphate (ATP) is recognized as the extracellular messenger that acts through P2 receptors. P2 receptors are divided into two subtypes: P2Y metabotropic receptors and P2X ionotropic receptors, both of which are found in virtually all mammalian cell types studied. Due to the difficulty in studying membrane protein structures by X-ray crystallography or NMR techniques, there is little information about these structures available in the literature. Two structures of the P2X4 receptor in truncated form have been solved by crystallography. Molecular modeling has proven to be an excellent tool for studying ionotropic receptors. Recently, modeling studies carried out on P2X receptors have advanced our knowledge of the P2X receptor structure-function relationships. This review presents a brief history of ion channel structural studies and shows how modeling approaches can be used to address relevant questions about P2X receptors.

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Evolution of the Ion Channel Concept: The Historical Perspective

Cited by 23 publications

References 92 publications

Could vesicular transport of Na+ and Cl– be a feature of salt tolerance in halophytes?

Could vesicular transport of Na+ and Cl– be a feature of salt tolerance in halophytes?

Multisensor Systems and Arrays for Medical Applications Employing Naturally-Occurring Compounds and Materials

Structural and Molecular Modeling Features of P2X Receptors

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