Evolution of the local calcium content around irradiated β-tricalcium phosphate ceramic implants: in vivo study in the rabbit

Huec, Jean Charles Le; Clément, Denis; Brouillaud, Brigitte; Barthe, Nicole; Dupuy, B.; Foliguet, B; Basse-Cathalinat, B.

doi:10.1016/s0142-9612(97)00189-0

Cited by 48 publications

(26 citation statements)

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“…The results of animal tests are very promising, and in vitro experimental studies have shown interesting resistance in compression, of around 45 MPa. As reported by Le Huec [35], these resorbable calcium phosphates provide the calcium for local bone formation and are of great interest for the treatment of osteoporotic fractures. Clinical applications on humans are in progress, but the results of these studies have not yet been published.…”

Section: Bone Substitutes In Vertebroplastymentioning

confidence: 96%

Vertebroplasty for osteoporotic spine fracture: prevention and treatment

2005

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IntroductionOsteoporosis is a disorder of decreased bone mass, microstructural collapse, and fragility fractures. It can affect people of all ethnic backgrounds and can result in challenging complications, ranging from compression fractures of vertebral bodies to femoral neck fractures [59]. The geriatric population is especially at risk for such osteoporotic fractures, as bone mass decreases with age [53]. A loss of one standard deviation of bone mass doubles the risk of spine fractures [34,56,59]. It is estimated that 90% of hip and spine fractures occurring in the elderly are attributable to osteoporosis [45]. The consequences of such osteoporotic vertebral fractures are diverse and include back pain, functional limitations and impairment of mood [11,37,58].A recent study in Canada examined the health-related quality of life (HRQL) in women aged 50 years and older with osteoporosis [1]. Subjects who had experienced a vertebral fracture had lower HRQL scores than participants without fracture in total score, symptoms, physical function, activities of daily living, and leisure. Acute complications of osteoporotic vertebral fractures include transient ileus, urinary retention, nausea, abdominal pain and chest pain [41,49]. Long-term effects of osteoporotic fracAbstract There is a relatively high prevalence of osteoporotic vertebral compression fractures (VCFs) in the elderly population, especially in women aged 50 or older. The result of these VCFs is increased morbidity and mortality in the short and long term. Medical treatment of these fractures includes bed rest, orthotics, analgesic medication and time. Percutaneous vertebroplasty (PVP) consists of percutaneous injection of biomaterial, such as methylmethacrylate, into the VCF to produce stability and pain relief. Biomechanical testing has shown that PVP can restore strength and stiffness of the vertebral body to the pre-fracture levels. Clinical results show immediate and maintained pain relief in 70-95% of the patients. Possible major complications include cement leakage into the spinal canal or into the venous system. Additionally, percutaneous vertebroplasty may alter the normal loading behavior of the adjacent vertebral body, and there is an increased risk of adjacent segment VCF. Kyphoplasty is a new technique, which introduces a balloon into the vertebral body transpedicularly to reduce the VCF while creating a cavity for the cement injection. This technique has the benefit of kyphosis reduction as well as less cement leakage. Research continues into the development of injectable biomaterials that are resorbable and allow for new bone formation. Vertebroplasty and kyphoplasty are safe and effective in the treatment of osteoporotic VCFs. They may allow for a faster return to function, and thus avoid the morbidity associated with medical treatment.

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Section: Bone Substitutes In Vertebroplastymentioning

confidence: 96%

Vertebroplasty for osteoporotic spine fracture: prevention and treatment

2005

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“…Together with this nutrient supply, a release of calcium and phosphate ions from the biomaterial surface takes places and is believed to be the origin of bioactivity of calcium phosphate biomaterials (143)(144)(145)). This process is followed by the precipitation of a biological carbonated apatite layer (that contains calcium-, phosphate-and other ions such as magnesium as well as proteins and other organic compounds) that occurs when the concentration of calcium and phosphate ions has reached super saturation level in the vicinity of the implant (142,(146)(147). This bone-like biological carbonated apatite layer is thought to be physiological trigger for stem cells to differentiate down the osteogenic lineage or could induce the release of growth factors that complement this process (142).…”

Section: Surface Propertiesmentioning

confidence: 99%

Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective

et al. 2013

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The role of Bone Tissue Engineering in the field of Regenerative Medicine has been the topic of substantial research over the past two decades. Technological advances have improved orthopaedic implants and surgical techniques for bone reconstruction. However, improvements in surgical techniques to reconstruct bone have been limited by the paucity of autologous materials available and donor site morbidity. Recent advances in the development of biomaterials have provided attractive alternatives to bone grafting expanding the surgical options for restoring the form and function of injured bone. Specifically, novel bioactive (second generation) biomaterials have been developed that are characterised by controlled action and reaction to the host tissue environment, whilst exhibiting controlled chemical breakdown and resorption with an ultimate replacement by regenerating tissue. Future generations of biomaterials (third generation) are designed to be not only osteoconductive but also osteoinductive, i.e. to stimulate regeneration of host tissues by combining tissue engineering and in situ tissue regeneration methods with a focus on novel applications. These techniques will lead to novel possibilities for tissue regeneration and repair. At present, tissue engineered constructs that may find future use as bone grafts for complex skeletal defects, whether from post-traumatic, degenerative, neoplastic or congenital/developmental "origin" require osseous reconstruction to ensure structural and functional integrity. Engineering functional bone using combinations of cells, scaffolds and bioactive factors is a promising strategy and a particular feature for future development in the area of hybrid materials which are able to exhibit suitable biomimetic and mechanical properties. This review will discuss the state of the art in this field and what we can expect from future generations of bone regeneration concepts.

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“…By radiolabelling calcium in b-tricalcium phosphate (b-TCP) ceramic, it has been shown that dissolution products originating from the implants were partially detected in the surrounding bone tissue [17]. In a number of studies in vitro, the presence of calcium phosphate ceramics has been shown to affect the levels of calcium and phosphate in the medium.…”

Section: Calcium Phosphate Bone Graft Substitutesmentioning

confidence: 99%