1991
DOI: 10.1073/pnas.88.2.537
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Evolution of the major histocompatibility complex: molecular cloning of major histocompatibility complex class I from the amphibian Xenopus.

Abstract: Class I major histocompatibility complex (MHC) cDNA clones have been isolated from an expression library derived from mRNA of an MHC homozygous Xenopus laevis. The nucleotide and predicted amino acid sequences show definite similarity to MHC class I molecules of higher vertebrates. The immunoglobulin-like a-3 domain is more similar to the immunoglobulin-like domains of mammalian class II (3 chains than to those of mammalian class I molecules, and a tree based on nucleotide sequences of representative MHC genes… Show more

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Cited by 84 publications
(29 citation statements)
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“…Although it is possible some of the sequences we identified were class Ib loci, our methodology provides evidence that the sequences are functional Ia alleles. Three other anuran species, R. temporaria, X. laevis and S. tropicalis express a single MHC class Ia locus (Flajnik et al, 1991(Flajnik et al, , 1993Teacher et al, 2009), but our study shows that numbers expressed of class Ia loci vary across major frog lineages (Table 5). We documented the presence of 2-3 expressed class Ia loci in other frog species, including three species within the genus Lithobates.…”
Section: Discussionmentioning
confidence: 67%
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“…Although it is possible some of the sequences we identified were class Ib loci, our methodology provides evidence that the sequences are functional Ia alleles. Three other anuran species, R. temporaria, X. laevis and S. tropicalis express a single MHC class Ia locus (Flajnik et al, 1991(Flajnik et al, , 1993Teacher et al, 2009), but our study shows that numbers expressed of class Ia loci vary across major frog lineages (Table 5). We documented the presence of 2-3 expressed class Ia loci in other frog species, including three species within the genus Lithobates.…”
Section: Discussionmentioning
confidence: 67%
“…Sequences are aligned to classical MHC class I sequences from A. mexicanum (Amme; U83137), X. laevis (Xela; DQ149606) and human (HLA-A*0201V; AJ621243). Domains are separated according to Flajnik et al (1991). Numbering is in reference to the consensus amino acids in the alignment.…”
Section: Number Of Expressed Mhc Class Ia Locimentioning
confidence: 99%
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“…One full-length and two truncated TAP1 clones were isolated along with P-glycoprotein clones (a gene that is closely related to TAP). A X. laevis f/f liver/thymus/spleen cDNA library [38] and the j/j intestine/ spleen cDNA library were subsequently screened using the full-length LG15 TAP1 insert under low-stringency conditions.…”
Section: Isolation Of Xenopus Tap1 and Tap2 Clonesmentioning
confidence: 99%
“…However, molecular modeling based on a comparison of the carboxy-terminal domains of numerous Hsp70s from different Annual Reviews www.annualreviews.org/aronline sources suggested an interesting similarity with the ~-1 and ~-2 domains of the human major histocompatability antigen (MHC) class I protein (56,165). One model proposes a peptide binding cleft for Hsp70 that, in contrast to that of the MHC class I molecule, would be lined predominantly by polar and charged amino acid residues (57).…”
Section: Molecular Mechanism Of H~p70 Actionmentioning
confidence: 99%