“…The development of ABMs that are based on general theories and first principles-so that they can be applied for different kind of OEUs, under different sets of biotic and abiotic circumstances, and at different spatiotemporal scales-has been a real challenge. For that, protocols, such as Pattern Oriented Modeling [88], Overview, Design concepts, and Details [89], and Approximate Bayesian Computation [90], have been proposed, evaluated [34,41,89,[91][92][93], and at least for one population successfully tested [94]. All this, as well as recent developments in trait-based approaches, molecular technologies, and big data approaches in general (Appendix 1), will help to further minimize the uncertainty and increase the general applicability of ABMs.…”