Evolution of thyroid hormone distributor proteins in fish

Yamauchi, Kiyoshi

doi:10.1016/j.ygcen.2021.113735

Cited by 7 publications

(4 citation statements)

References 119 publications

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“…TTR was not found in the beloniformes studied, including four different medaka species. 65 The preferred affinity of THs from TH distributor proteins in early life stages of medaka is unknown, and a higher affinity for T 4 could explain that T 4 seems to be more effective than T 3 in our transgenic model. Further studies are required to clarify the proteins involved in TH transport in medaka.…”

Section: ■ Materials and Methodsmentioning

confidence: 90%

“…But interestingly, according to Yamauchi, the TTR gene is highly order-specific and may have been lost in some teleost groups. TTR was not found in the beloniformes studied, including four different medaka species . The preferred affinity of THs from TH distributor proteins in early life stages of medaka is unknown, and a higher affinity for T 4 could explain that T 4 seems to be more effective than T 3 in our transgenic model.…”

Section: Resultsmentioning

confidence: 99%

“…63 The principal TH-transporting plasma protein in teleost fish and amphibians is transthyretin (TTR), with a higher affinity for T 3 than for T 4 . 64 But interestingly, according to Yamauchi, 65 the TTR gene is highly order-specific and may have been lost in some teleost groups. TTR was not found in the beloniformes studied, including four different medaka species.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

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A Novel Transgenic Model to Study Thyroid Axis Activity in Early Life Stage Medaka

Pesce,

Garde,

Rigolet

et al. 2023

Environ. Sci. Technol.

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Identifying endocrine disrupting chemicals in order to limit their usage is a priority and required according to the European Regulation. There are no Organization for Economic Co-operation and Development (OECD) test guidelines based on fish available for the detection of Thyroid axis Active Chemicals (TACs). This study aimed to fill this gap by developing an assay at eleuthero-embryonic life stages in a novel medaka (Oryzias latipes) transgenic line. This transgenic line expresses green fluorescent protein (GFP) in thyrocytes, under the control of the medaka thyroglobulin gene promoter. The fluorescence expressed in the thyrocytes is inversely proportional to the thyroid axis activity. When exposed for 72 h to activators (triiodothyronine (T3) and thyroxine (T4)) or inhibitors (6-N-propylthiouracil (PTU), Tetrabromobisphenol A (TBBPA)) of the thyroid axis, the thyrocytes can change their size and express lower or higher levels of fluorescence, respectively. This reflects the regulation of thyroglobulin by the negative feedback loop of the Hypothalamic–Pituitary–Thyroid axis. T3, T4, PTU, and TBBPA induced fluorescence changes with the lowest observable effect concentrations (LOECs) of 5 μg/L, 1 μg/L, 8 mg/L, and 5 mg/L, respectively. This promising tool could be used as a rapid screening assay and also to help decipher the mechanisms by which TACs can disrupt the thyroid axis in medaka.

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Section: ■ Materials and Methodsmentioning

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Section: ■ Materials and Methodsmentioning

confidence: 99%

See 1 more Smart Citation

A Novel Transgenic Model to Study Thyroid Axis Activity in Early Life Stage Medaka

Pesce,

Garde,

Rigolet

et al. 2023

Environ. Sci. Technol.

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“…However, interpreting EPH profiles with regard to health remains challenging, and further investigation is warranted, including determination of which proteins constitute EPH fractions in pompano and other teleosts. TTR, albumin‐like proteins (high‐density lipoproteins), alpha‐1 globulins (alpha‐1‐antitrypsin, transcortin, alpha‐1‐acid glycoprotein, and apolipoprotein‐A1), alpha‐2 globulins (acute phase proteins [APP], ceruloplasmin, haptoglobin, and alpha‐2‐macroglobulin), beta‐globulins (transferrin, angiostatin, hemopexin, beta‐2‐microglobulin, properdin, and low‐density beta‐lipoproteins), and gamma globulins (IgM, IgD, IgT/Z, fibrinogen, and c‐reactive protein) have all been identified in teleosts, but further research is needed to identify these proteins in Florida pompano and determine their patterns of fractionation (Andreeva et al, 2020; Bilal et al, 2021; Castellano et al, 2020; Charlie‐Silva et al, 2019; Pérez‐Sánchez et al, 2017; Power et al, 2000; Yamauchi, 2021).…”

Section: Discussionmentioning

confidence: 99%

Hematological changes in Florida pompano (Trachinotus carolinus) supplemented with β‐glucan and Pediococcus acidilactici synbiotic

Morgan,

Fogelson,

Wills

et al. 2024

Journal of Fish Biology

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Florida pompano (Trachinotus carolinus) are a species of growing interest for commercial aquaculture. Effective health monitoring is crucial to the successful growout of the species, and prophylactic and therapeutic use of chemicals and antibiotics has been the traditional strategy for promoting stock health. However, concerns about antimicrobial resistance, chemical residues in seafood products and the environment, and resultant immunosuppression have prompted the industry to identify alternative management strategies, including supplementation with prebiotics, probiotics, and combinations of both (synbiotics). The objectives of this study are to determine and compare hematological, plasma biochemical, and plasma protein electrophoresis data of synbiotic‐supplemented (β‐glucan and Pediococcus acidilactici) and non‐supplemented Florida pompano. Reference intervals for blood analytes are provided for both groups and for subgroups (females, males, large, and small fish) where statistically significant results exist. There are no differences between the hematological and plasma biochemistry analytes between the supplemented and control groups, except for blood urea nitrogen and carbon dioxide, indicating a possible effect of synbiotic supplementation on gill function and osmoregulation. Sex‐related and size‐related differences are observed within each of the control and supplemented groups; however, biometric measurements do not strongly correlate with blood analytes. These data represent baseline hematological and plasma biochemical data in the Florida pompano and indicate the safety of synbiotic supplementation in this commercially important species. This study serves to further the commercialization of Florida pompano by providing blood analyte reference intervals for health monitoring in the aquaculture setting.

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Binding interaction of typical emerging contaminants on Gobiocypris rarus transthyretin: an in vitro and in silico study

Li,

Liu,

Zhao

et al. 2024

Front. Environ. Sci. Eng.

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Evolution of thyroid hormone distributor proteins in fish

Cited by 7 publications

References 119 publications

A Novel Transgenic Model to Study Thyroid Axis Activity in Early Life Stage Medaka

A Novel Transgenic Model to Study Thyroid Axis Activity in Early Life Stage Medaka

Hematological changes in Florida pompano (Trachinotus carolinus) supplemented with β‐glucan and Pediococcus acidilactici synbiotic

Binding interaction of typical emerging contaminants on Gobiocypris rarus transthyretin: an in vitro and in silico study

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