This paper considers influence of elevated irradiation temperature on structure and properties of 15Kh2NMFAA reactor pressure vessel (RPV) steel. The steel is investigated after accelerated irradiation at 300 ∘ C (operating temperature of VVER-1000-type RPV) and 400∘ C supposed to be the operating temperature of advanced RPVs. Irradiation at 300 ∘ C leads to formation of radiationinduced precipitates and radiation defects-dislocation loops, while no carbide phase transformation is observed. Irradiation at a higher temperature (400 ∘ C) neither causes formation of radiation-induced precipitates nor provides formation of dislocation loops, but it does increase the number density of the main initial hardening phase-of the carbonitrides. Increase of phosphorus concentration in grain boundaries is more pronounced for irradiation at 400 ∘ C as compared to irradiation at 300 ∘ C due to influence of thermally enhanced diffusion at a higher temperature. The structural-phase changes determine the changes of mechanical properties: at both irradiation temperatures irradiation embrittlement is mainly due to the hardening mechanism with some contribution of the nonhardening one for irradiation at 400 ∘ C. Lack of formation of radiation-induced precipitates at = 400 ∘ C provides a small Δ shift (17 ∘ C). The obtained results demonstrate that the investigated 15Kh2NMFAA steel may be a promising material for advanced reactors with an elevated operating temperature.