2022
DOI: 10.1093/g3journal/jkac204
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Evolutionarily conserved role of hps1 in melanin production and blood coagulation in medaka fish

Abstract: Hermansky-Pudlak syndrome is an autosomal recessive disease characterized by albinism, visual impairment, and blood platelet dysfunction. One of the genes responsible for Hermansky-Pudlak syndrome, hps1, regulates organelle biogenesis and thus plays important roles in melanin production, blood clotting, and the other organelle-related functions in humans and mice. However, the function of hps1 in other species remains poorly understood. In this study, we discovered albino medaka fish during the maintenance of … Show more

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“…2.13 RNA sequencing (RNA-seq) and Gene ontology (GO) analysis RNA-sequencing (RNA-seq) analysis was performed as described in a previous study (32). Whole bodies of germ-free (pools of two fish, n = 3) and conventional (pools of two fish, n = 3) larvae at 14 dpf were kept in RNAprotect reagent (Qiagen, Hilden, Germany) at 4°C.…”
Section: Histological Analysismentioning
confidence: 99%
“…2.13 RNA sequencing (RNA-seq) and Gene ontology (GO) analysis RNA-sequencing (RNA-seq) analysis was performed as described in a previous study (32). Whole bodies of germ-free (pools of two fish, n = 3) and conventional (pools of two fish, n = 3) larvae at 14 dpf were kept in RNAprotect reagent (Qiagen, Hilden, Germany) at 4°C.…”
Section: Histological Analysismentioning
confidence: 99%