Evolutionary analysis of the Musashi family: What can it tell us about Zika?

Caldas-Garcia, Gabriela Barreto; Schüler‐Faccini, Lavínia; Pissinatti, Alcides; Paixão‐Côrtes, Vanessa Rodrigues; Bortolini, María Cátira

doi:10.1016/j.meegid.2020.104364

Cited by 4 publications

(2 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As revealed by the study of Zika virus-induced microcephaly, the roles of Msi in stem cell maintenance, cell proliferation, and cell fate determination appear relevant to understanding the pathophysiology of this developmental disorder of the brain. The emergence of a Zika virus (ZIKV) epidemic in Brazil in 2016 showed that children that were exposed to the virus infection in the uterus developed defects ranging from mild developmental delay to severe microcephaly and other severe brain abnormalities (Kindhauser et al, 2016 ; Caldas-Garcia et al, 2020 ). Resulting from multiple efforts to understand the mechanisms of action of the virus, mammalian Msi1 was eventually shown to interact with the Zika genome (Chavali et al, 2017 ).…”

Section: The Musashi Rna Binding Protein Family As Master Regulators Of Neuronal Developmentmentioning

confidence: 99%

The Fine Art of Writing a Message: RNA Metabolism in the Shaping and Remodeling of the Nervous System

Landínez-Macías

Urwyler

2021

Front. Mol. Neurosci.

View full text Add to dashboard Cite

Neuronal morphogenesis, integration into circuits, and remodeling of synaptic connections occur in temporally and spatially defined steps. Accordingly, the expression of proteins and specific protein isoforms that contribute to these processes must be controlled quantitatively in time and space. A wide variety of post-transcriptional regulatory mechanisms, which act on pre-mRNA and mRNA molecules contribute to this control. They are thereby critically involved in physiological and pathophysiological nervous system development, function, and maintenance. Here, we review recent findings on how mRNA metabolism contributes to neuronal development, from neural stem cell maintenance to synapse specification, with a particular focus on axon growth, guidance, branching, and synapse formation. We emphasize the role of RNA-binding proteins, and highlight their emerging roles in the poorly understood molecular processes of RNA editing, alternative polyadenylation, and temporal control of splicing, while also discussing alternative splicing, RNA localization, and local translation. We illustrate with the example of the evolutionary conserved Musashi protein family how individual RNA-binding proteins are, on the one hand, acting in different processes of RNA metabolism, and, on the other hand, impacting multiple steps in neuronal development and circuit formation. Finally, we provide links to diseases that have been associated with the malfunction of RNA-binding proteins and disrupted post-transcriptional regulation.

show abstract

Section: The Musashi Rna Binding Protein Family As Master Regulators Of Neuronal Developmentmentioning

confidence: 99%

The Fine Art of Writing a Message: RNA Metabolism in the Shaping and Remodeling of the Nervous System

Landínez-Macías

Urwyler

2021

Front. Mol. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Many species of NHP have been shown to be susceptible to ZIKV and used as experimental models for ZIKV infection including the rhesus macaque ( Macaca mulatta ) ( Abbink et al, 2016 ; Dudley et al, 2016 ; Aid et al, 2017 ; Coffey et al, 2017 , 2018 ; Hirsch et al, 2017 , 2018 ; Nguyen et al, 2017 ; Magnani et al, 2018 ; Martinot et al, 2018 ; Rayner et al, 2018 ), pigtail macaque ( Macaca nemestrina ) ( Adams Waldorf et al, 2018a ; O’Connor et al, 2018 ), cynomolgus macaque ( Macaca fascicularis ) ( Koide et al, 2016 ; Schouest et al, 2020 ), olive baboon ( Papio anubis ) ( Gurung et al, 2018 ; Gurung et al, 2020 ), chacma baboon ( Papio ursinus ) ( Wastika et al, 2019 ), yellow baboon ( Papio cynocephalus ) ( Buechler et al, 2017 ), and the malbrouck ( Chlorocebus cynosuros ) ( Wastika et al, 2019 ), marmoset ( Callithrix jacchus ) ( Chiu et al, 2017 ; Lum et al, 2018 ; Seferovic M. et al, 2018 ; Berry et al, 2019 ), black-tufted marmoset ( Callithrix penicillata ) ( Terzian et al, 2018 ), tamarin ( Saguinus labiatus ) ( Berry et al, 2019 ), squirrel monkey ( Saimiri sp.) ( Vanchiere et al, 2018 ), capuchin monkey ( Sapajus libidinosus ) ( Favoretto et al, 2016 ; de Oliveira-Filho et al, 2018 ; Favoretto et al, 2019 ), and vervet or African Green monkey ( C. aethiops ) ( Caldas-Garcia et al, 2020 ; Haddow et al, 2020 ). Animal models of adult and congenital ZIKV infection demonstrated broad viral tropism for cells and tissues throughout the body including the brain, spinal cord, placenta, testis/epididymis, ovary, uterus, multiple lymphoid tissues, joints, heart, and lungs ( Adams Waldorf et al, 2016 , 2018a ; Chan et al, 2016 ; Cugola et al, 2016 ; Lazear et al, 2016 ; Ma et al, 2016 ; Miner et al, 2016 ; Mysorekar and Diamond, 2016 ; Sapparapu et al, 2016 ;…”

Section: Nhp Models Of Zikv Teratogenesismentioning

confidence: 99%

Non-human Primate Models to Investigate Mechanisms of Infection-Associated Fetal and Pediatric Injury, Teratogenesis and Stillbirth

Brokaw

Furuta

et al. 2021

Front. Genet.

View full text Add to dashboard Cite

A wide array of pathogens has the potential to injure the fetus and induce teratogenesis, the process by which mutations in fetal somatic cells lead to congenital malformations. Rubella virus was the first infectious disease to be linked to congenital malformations due to an infection in pregnancy, which can include congenital cataracts, microcephaly, hearing impairment and congenital heart disease. Currently, human cytomegalovirus (HCMV) is the leading infectious cause of congenital malformations globally, affecting 1 in every 200 infants. However, our knowledge of teratogenic viruses and pathogens is far from complete. New emerging infectious diseases may induce teratogenesis, similar to Zika virus (ZIKV) that caused a global pandemic in 2016–2017; thousands of neonates were born with congenital microcephaly due to ZIKV exposure in utero, which also included a spectrum of injuries to the brain, eyes and spinal cord. In addition to congenital anomalies, permanent injury to fetal and neonatal organs, preterm birth, stillbirth and spontaneous abortion are known consequences of a broader group of infectious diseases including group B streptococcus (GBS), Listeria monocytogenes, Influenza A virus (IAV), and Human Immunodeficiency Virus (HIV). Animal models are crucial for determining the mechanism of how these various infectious diseases induce teratogenesis or organ injury, as well as testing novel therapeutics for fetal or neonatal protection. Other mammalian models differ in many respects from human pregnancy including placentation, labor physiology, reproductive tract anatomy, timeline of fetal development and reproductive toxicology. In contrast, non-human primates (NHP) most closely resemble human pregnancy and exhibit key similarities that make them ideal for research to discover the mechanisms of injury and for testing vaccines and therapeutics to prevent teratogenesis, fetal and neonatal injury and adverse pregnancy outcomes (e.g., stillbirth or spontaneous abortion). In this review, we emphasize key contributions of the NHP model pre-clinical research for ZIKV, HCMV, HIV, IAV, L. monocytogenes, Ureaplasma species, and GBS. This work represents the foundation for development and testing of preventative and therapeutic strategies to inhibit infectious injury of human fetuses and neonates.

show abstract

Evolutionary analysis of the anti-viral STAT2 gene of primates and rodents: Signature of different stages of an arms race

Landau

Fam

Yépez

et al. 2021

Infection, Genetics and Evolution

View full text Add to dashboard Cite

Evolutionary analysis of the Musashi family: What can it tell us about Zika?

Cited by 4 publications

References 88 publications

The Fine Art of Writing a Message: RNA Metabolism in the Shaping and Remodeling of the Nervous System

The Fine Art of Writing a Message: RNA Metabolism in the Shaping and Remodeling of the Nervous System

Non-human Primate Models to Investigate Mechanisms of Infection-Associated Fetal and Pediatric Injury, Teratogenesis and Stillbirth

Evolutionary analysis of the anti-viral STAT2 gene of primates and rodents: Signature of different stages of an arms race

Contact Info

Product

Resources

About