Evolutionary aspects of autotrophy.

Quayle, J R; Ferenci, T

doi:10.1128/mmbr.42.2.251-273.1978

Cited by 88 publications

(44 citation statements)

References 52 publications

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“…It is equally possible, using similar arguments, to describe the current distribution of the Entner-Doudoroff pathway in nature in a way that satisfactorily explains its presence in the face of the obviously more efficient Embden-Meyerhof-Parnas pathway. Readers are referred to writings by Gest and Schopf [148], by Fothergill-Gillmore [149], and by Quayle and Ferenci [150] for extensive reviews on the subject of metabolic evolution. Romano and Saier [151] have summarized the arguments, supported by experimental evidence, which suggest that the Entner-Doudoroff pathway predates the Embden-Meyerhof-Parnas pathway.…”

Section: Evolution Of the Pathwaymentioning

confidence: 99%

“…Although some controversy remains, it is generally accepted that the primitive Earth atmosphere was anaerobic, consisting of inorganic chemicals that could give rise to carboxylic acids, amino acids, aldehydes, sugars, purines, etc. [148,150]. Sugars would have been formed through a series of abiotic reactions involving formaldehyde [150].…”

Section: Evolution Of the Pathwaymentioning

confidence: 99%

“…[148,150]. Sugars would have been formed through a series of abiotic reactions involving formaldehyde [150]. Glucose, being the most stable of the hexoses, would have had the greatest opportunity to accumulate in the primordial soup [148].…”

Section: Evolution Of the Pathwaymentioning

confidence: 99%

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The Entner-Doudoroff pathway: history, physiology and molecular biology

Conway¹

1992

FEMS Microbiology Letters

321

194

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The Entner‐Doudoroff pathway is now known to be very widely distributed in nature. Biochemical and physiological studies show that the Entner‐Doudoroff pathway can operate in a linear and catabolic mode, in a ‘cyclic’ mode, in a modified mode involving non‐phosphorylated intermediates, or in alternative modes involving C1 metabolism and anabolism. Molecular and genetic analyses of the Entner‐Doudoroff pathway in Zymomonas mobilis, Escherichia coli and Pseudomonas aeruginosa have led to an improved understanding of some fundamental aspects of metabolic controls. It can be argued that the Entner‐Doudoroff pathway is more primitive than Embden‐Meyerhof‐Parnas glycolysis.

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Section: Evolution Of the Pathwaymentioning

confidence: 99%

Section: Evolution Of the Pathwaymentioning

confidence: 99%

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The Entner-Doudoroff pathway: history, physiology and molecular biology

Conway¹

1992

FEMS Microbiology Letters

321

194

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“…The ribulose monophosphate (RuMP) pathway for formaldehyde ¢xation exists in a wide range of bacteria which can grow on C 1 compounds such as methane, methanol, and methylated amines. Bacteria possessing this pathway have been reported to make a signi¢cant contribution to the ecological carbon cycle [1]. The RuMP pathway begins with a reaction catalyzed by two unique enzymes, 3-hexulose-6phosphate synthase (HPS) and 6-phospho-3-hexuloisomerase (PHI) [1], and is postulated to involve several enzymes from the pentose phosphate pathway and the Entner-Doudoro¡ pathway.…”

Section: Introductionmentioning

confidence: 99%

“…Bacteria possessing this pathway have been reported to make a signi¢cant contribution to the ecological carbon cycle [1]. The RuMP pathway begins with a reaction catalyzed by two unique enzymes, 3-hexulose-6phosphate synthase (HPS) and 6-phospho-3-hexuloisomerase (PHI) [1], and is postulated to involve several enzymes from the pentose phosphate pathway and the Entner-Doudoro¡ pathway. This information was obtained from the biochemical analysis of RuMP pathway bacteria.…”

Section: Introductionmentioning

confidence: 99%

Organization of the genes involved in the ribulose monophosphate pathway in an obligate methylotrophic bacterium, Methylomonas aminofaciens 77a

Sakai

1999

FEMS Microbiology Letters

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The 4.4-kb PstI fragment harboring the gene encoding 3-hexulose-6-phosphate synthase, rmpA, which was previously cloned from the chromosome of an obligate methylotroph, Methylomonas aminofaciens 77a, was investigated in detail. In addition to the rmpA gene, the fragment contained three open reading frames encoding transaldolase (rmpD), IS10-R (rmpI), and 6-phospho-3-hexuloisomerase (PHI) (rmpB). The rmpB gene product was overproduced in Escherichia coli cells, purified to homogeneity, and then enzymatically identified as PHI. The gene organization of the ribulose monophosphate pathway enzymes together with a transposon, IS10-R, is discussed from both evolutionary and regulatory aspects. ß

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Metabolic Features of Methane‐ and Methanol‐Utilizing Bacteria

Trotsenko

1983

Acta Biotechnologica

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Investigations of a wide range of methane-and methanol-utilizers showed a striking versatility of their metabolism dependent on the genotype and growth conditions. A correlation between pathways of carbon and nitrogen metabolism was found. It was most stringent in obligate metheneutilizers: the hexulosephosphnte pathway bacteria assimilated NH, by the reductive amination of a-ketoglutarate or pyruvate whereas the serine pathway bacteria used the glutamate cycle (glutamine synthetase + glutamate-osoglutarate aminotransferase).Multiple enzymic lesions were found in central metabolism of obligate methylotrophs, i.e. the absence of the enzymes of glycolytic and pentosephosphate pathways, gluconeogenesis, citric acid cycle and glyoxylate shunt. These metabolic blocks were not so profound and could be compensated in restricted and facultative methylotrophs during heterotrophio growth. The average levels of exogenous C 0 2 fixation in methylotrophic bacteria with the hexulosephosphate, serine and ribulosebisphosphate pathways were found to be 10, 30 and 80% of their total cell carbon, respectively. These results served as a basis for biotechnological applications of metabolic potential of methylotrophs (production of biomass, polysaccharidea and enzymes as well as for microbiological treatment of industrial waters containing toxic C,and C,-compounds). ZusammenfassungUntersuchungen an einer grof3en Anzahl von Methan und Methanol verwertenden Mikmorganismen zeigten, in welcher Vielfalt der Metabolismus vom Genotyp und von den Wachstumsbedingungen abhltngig sein kann. Zwischen den Pathways des Kohlenstoff-und Stickstoffmetabolismus wurden Korrelationen gefunden. Dabei gilt fiir obligate Methan-Verwerter : Hexulosephosphat-Weg-Bakterien assimilieren Ammoniak durch reduktive Aminierung von a-Ketoglutarat oder Pyruvat. Serin-Weg-Bakterien nutzen den Glutamat-Cyclus (Glutaminsynthetase und. Glutamat-Oxoglutarat-Aminotransferase). Bei obligat methylotrophen Mikroorganismen wurde hiiufig das Fehlen von Enzymen zentraler Pathways wie der Glykolyse, des Pentosephosphat-Wee, der Gluconeogenese, des Citrat-Cyclus und des Glyoxalat-Cyclus ,beobachtet. Diese metabolischen Blocks waren jedoch nicht so vollstiindig; sie konnten in restriktiven und fakultativen Methylotrophen unter heterotrophen Wachstumsbedingungen ausgeglichen werden. Die exogene CO,-Fixierung triigt in methylotrophen Bakterien mit dem Hexulosephosphat-Weg zu 10%. mit dem Serien-Weg zu 30% und mit dem Ribulosediphosphat-Weg zu 80% zum Kohlenstoffgehalt der Zellen bei (Durchschnittswerte). Die genannten Ergebnisse kBnnen Grundlagen far die biotechnologische Anwendung der metabolischen Fiihigkeiten von Methylotrophen z. B. bei der Biomasseproduktion, der Gewinnung von Polysacchariden und Enzymen bzw. der mikrobiologischen Behandlung von Industrieabwiissern mit toxischen C,und C,-Verbindungen sein.

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Evolutionary aspects of autotrophy.

Cited by 88 publications

References 52 publications

The Entner-Doudoroff pathway: history, physiology and molecular biology

The Entner-Doudoroff pathway: history, physiology and molecular biology

Organization of the genes involved in the ribulose monophosphate pathway in an obligate methylotrophic bacterium, Methylomonas aminofaciens 77a

Metabolic Features of Methane‐ and Methanol‐Utilizing Bacteria

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