Evolutionary Aspects of Physiological Function and Molecular Diversity of the Oxytocin/Vasopressin Signaling System

Liutkevičiūtė, Zita; Gruber, Christian W.

doi:10.1002/9781118760369.ch1

Cited by 3 publications

(5 citation statements)

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“…*P value reflects treatment effect over all data. ant species (7). Our findings that the receptor was expressed throughout the body and the peptide was produced in the brain and presumably released into the periphery allowed us to speculate that inotocin function is not limited to a specific organ but may hold a more general physiologic role, such as feeding, energy conservation, or metabolic homeostasis.…”

Section: Discussionmentioning

confidence: 81%

“…In contrast, fish can contain a greater number of OT/VP-like receptors and peptides, and invertebrates generally express only 1 peptide and 1 receptor. All vertebrate OT-and VP-like peptides are considered to have evolved from the ancestral nonapeptide vasotocin by gene duplication (6,7).…”

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confidence: 99%

“…It was suggested that the inotocin (insect OT/VP-like) signaling system may be involved in larval development and water homeostasis. Recently it has become evident that most insect orders contain components of this peptidergic signaling system (3,7). We identified transcripts encoding the inotocin receptor (IR) and the inotocin precursor (IP) in 20 ant species (3,22).…”

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confidence: 99%

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Oxytocin‐like signaling in ants influences metabolic gene expression and locomotor activity

et al. 2018

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Ants are emerging model systems to study cellular signaling because distinct castes possess different physiologic phenotypes within the same colony. Here we studied the functionality of inotocin signaling, an insect ortholog of mammalian oxytocin (OT), which was recently discovered in ants. In Lasius ants, we determined that specialization within the colony, seasonal factors, and physiologic conditions down-regulated the expression of the OT-like signaling system. Given this natural variation, we interrogated its function using RNAi knockdowns. Next-generation RNA sequencing of OT-like precursor knock-down ants highlighted its role in the regulation of genes involved in metabolism. Knock-down ants exhibited higher walking activity and increased self-grooming in the brood chamber. We propose that OT-like signaling in ants is important for regulating metabolic processes and locomotion.-Liutkevičiūtė, Z., Gil-Mansilla, E., Eder, T., Casillas-Pérez, B., Di Giglio, M. G., Muratspahić, E., Grebien, F., Rattei, T., Muttenthaler, M., Cremer, S., Gruber, C. W. Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity.

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Section: Discussionmentioning

confidence: 81%

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confidence: 99%

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Oxytocin‐like signaling in ants influences metabolic gene expression and locomotor activity

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“…Being present across a range of distantly-related animal species and dating back more than 600 million years in evolution, it has been an intriguing model system for comparative endocrinology and neurophysiology1920. Furthermore oxytocin/vasopressin-like signalling has been extensively studied for its biological function, which appears to be conserved across vertebrates and invertebrates919.…”

Section: Discussionmentioning

confidence: 99%

Global map of oxytocin/vasopressin-like neuropeptide signalling in insects

Liutkevičiūtė

Koehbach

Eder

et al. 2016

Sci Rep

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Oxytocin and vasopressin mediate a range of physiological functions that are important for osmoregulation, reproduction, social behaviour, memory and learning. The origin of this signalling system is thought to date back ~600 million years. Oxytocin/vasopressin-like peptides have been identified in several invertebrate species and they appear to be functionally related across the entire animal kingdom. There is little information available about the biology of this peptide G protein-coupled receptor signalling system in insects. Recently over 200 insect genome/transcriptome datasets were released allowing investigation of the molecular structure and phylogenetic distribution of the insect oxytocin/vasopressin orthologue – inotocin peptides and their receptors. The signalling system is present in early arthropods and representatives of some early-diverging lineages. However, Trichoptera, Lepidoptera, Siphonaptera, Mecoptera and Diptera, lack the presence of inotocin genes, which suggests the peptide-receptor system was probably lost in their common ancestor ~280 million-years-ago. In addition we detected several losses of the inotocin signalling system in Hemiptera (white flies, scale insects and aphids), and the complete absence in spiders (Chelicerata). This unique insight into evolutionarily patterns and sequence diversity of neuroendocrine hormones will provide opportunities to elucidate the physiology of the inotocin signalling system in one of the largest group of animals.

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“…3) (Koehbach et al, 2013; Liutkeviciute and Gruber, 2015). Several points can be taken from this analysis.…”

Section: Ot and Avp Receptor Diversity In Nwmmentioning

confidence: 99%

Neuropeptide diversity and the regulation of social behavior in New World primates

French

Taylor

Mustoe

et al. 2016

Frontiers in Neuroendocrinology

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Oxytocin (OT) and vasopressin (AVP) are important hypothalamic neuropeptides that regulate peripheral physiology, and have emerged as important modulators of brain function, particularly in the social realm. OT structure and the genes that ultimately determine structure are highly conserved among diverse eutherian mammals, but recent discoveries have identified surprising variability in OT and peptide structure in New World monkeys (NWM), with five new OT variants identified to date. This review explores these new findings in light of comparative OT/AVP ligand evolution, documents coevolutionary changes in the oxytocin and vasopressin receptors (OTR and V1aR), and highlights the distribution of neuropeptidergic neurons and receptors in the primate brain. Finally, the behavioral consequences of OT and AVP in regulating NWM sociality are summarized, demonstrating important neuromodulatory effects of these compounds and OT ligand-specific influences in certain social domains.

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Evolutionary Aspects of Physiological Function and Molecular Diversity of the Oxytocin/Vasopressin Signaling System

Cited by 3 publications

References 32 publications

Oxytocin‐like signaling in ants influences metabolic gene expression and locomotor activity

Oxytocin‐like signaling in ants influences metabolic gene expression and locomotor activity

Global map of oxytocin/vasopressin-like neuropeptide signalling in insects

Neuropeptide diversity and the regulation of social behavior in New World primates

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