2015
DOI: 10.1016/j.tube.2015.02.022
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Evolutionary changes in the genome of Mycobacterium tuberculosis and the human genome from 9000 years BP until modern times

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Cited by 38 publications
(11 citation statements)
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“…In some cases, PCR analyses of DNA extracts, coupled with limited sequencing and/ or hybridization with CRISPR spacers, have provided presumptive genetic evidence that these lesions did arise from M. tuberculosis infections of humans and wild animals [58]. Those analyses dated human infections in Israel to 9000 years ago [59] and tuberculosis of wild bison in North America to 17 000 years ago [60]. It has been suggested that aDNA from Mycobacterium is less exposed to DNA damage than that of other bacterial taxa, because mycobacterial cell walls contain mycolic acid [61].…”
Section: How Long Have Humans Been Afflicted By Tuberculosis?mentioning
confidence: 99%
“…In some cases, PCR analyses of DNA extracts, coupled with limited sequencing and/ or hybridization with CRISPR spacers, have provided presumptive genetic evidence that these lesions did arise from M. tuberculosis infections of humans and wild animals [58]. Those analyses dated human infections in Israel to 9000 years ago [59] and tuberculosis of wild bison in North America to 17 000 years ago [60]. It has been suggested that aDNA from Mycobacterium is less exposed to DNA damage than that of other bacterial taxa, because mycobacterial cell walls contain mycolic acid [61].…”
Section: How Long Have Humans Been Afflicted By Tuberculosis?mentioning
confidence: 99%
“…Exome sequencing has been exploited to evaluate gene variants associated with certain cancers, however, its use in the study of susceptibility to infectious diseases is still limited [ 15 , 16 ]. Tuberculosis infection and disease has a long history of association with the human race [ 17 , 18 ] and given its intricate relationship with the host, it is not surprising that certain genes and gene variants or mutations have been thought to be involved in the ability of the host to fight the infection and/or halt its progression to disease.…”
Section: Resultsmentioning
confidence: 99%
“…Only about 10 % of carriers of M. tuberculosis develop the disease, thereby indicating the importance of alleles coding for resistance in the formation of a pathogen-resistant phenotype [ 87 ]. However, it should also be remembered that other non-genetic factors influence human susceptibility to infection, such as co-morbidity, co-infections, dietary deficiencies, stress and trauma [ 88 ]. The significance of the host genome in the development of mycobacterial diseases has been confirmed by studies on mono- and di-zygotic twins and by documented differences in disease incidence around the world, correlated with the history of the disease in different regions [ 89 ].…”
Section: Significance Of the Host Genome In Mycobacterial Diseasesmentioning
confidence: 99%
“…Thus, further research on host genes related to susceptibility/resistance to mycobacterial diseases is crucial in order to identify the mycobacterial resistant genotype in different populations and enabling the recognition of changes in allele frequencies. Extending this to aDNA studies, limited data are now available for amplified aDNA from 18 individuals from the 18th century Vác, Hungary and early Christian Nubia [ 88 ].…”
Section: Significance Of the Host Genome In Mycobacterial Diseasesmentioning
confidence: 99%