Evolutionary conservations, changes of circadian rhythms and their effect on circadian disturbances and therapeutic approaches

Palm, D.; Uzoni, Adriana; Simon, Frederick; Fischer, Matthias; Coogan, Andrew N.; Tucha, Oliver; Thome, Johannes; Faltraco, Frank

doi:10.1016/j.neubiorev.2021.06.007

Cited by 11 publications

(6 citation statements)

References 300 publications

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“…Among the pathways, three stand out, the pathway of fanconi anemia (hsa03460), circadian entrainment (hsa04713), and dopaminergic synapse (hsa04728), which we have found a relation with a couple of publications [ 42 , 43 ](Gluten-Free Diet for the Treatment of ADHD; Pilot Study) where in a case study they describe the difficulty of finding a diagnosis to a series of neuropsychiatric manifestations, described as “non-celiac gluten sensitivity” (NCGS), where a series of symptoms related to the consumption of gluten-containing foods (wheat) are characterized in people not affected by celiac disease (CD) or wheat allergy (AW).). Attention deficit hyperactivity disorder (ADHD) related to the circadian entrainment pathway [ 44 ], and schizophrenia related to the dopaminergic synaptic pathway, are some of the main symptoms related to wheat consumption in case studies, in addition, including a low-ferritin anemia in the clinical picture. Despite attempts to consolidate a possible explanation, this has not been achieved due to lack of information on response mechanisms or genetic components of the disease and therefore the number of people who may be affected is uncertain.…”

Section: Discussionmentioning

confidence: 99%

Identification of potential target genes in Homo sapiens, by miRNA of Triticum aestivum: A cross kingdom computational approach

Sánchez-Romo

Hernández-Vásquez

Pereyra-Alférez

et al. 2022

Non-coding RNA Research

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Section: Discussionmentioning

confidence: 99%

Identification of potential target genes in Homo sapiens, by miRNA of Triticum aestivum: A cross kingdom computational approach

Sánchez-Romo

Hernández-Vásquez

Pereyra-Alférez

et al. 2022

Non-coding RNA Research

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“…This disturbance may act as a contributing factor to the onset of neurodevelopmental disorders, as suggested by Palm et al. (2021).…”

Section: Discussionmentioning

confidence: 88%

Impact of food additives on neurodevelopmental processes in zebrafish (Danio rerio): Exploring circadian clock genes and dopamine system

Christy,

Vignesh,

Nellore

et al. 2024

Developmental Neurobiology

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Assessing the impact of food additives on neurodevelopmental processes extends beyond traditional acute toxicity evaluations to address subtler, long‐term effects. This study investigates the impact of common food additives (tartrazine, sunset yellow, sodium benzoate, and aspartame) on neurodevelopment in zebrafish embryos, observed from 18 hours postfertilization (hpf) to 91 days postfertilization (dpf). Results show reduced 96 hpf locomotor activity after aspartame exposure, with elevated additives correlating with decreased heart rates and induced neurodegenerative phenotypes, including bent tails and abnormal pigmentation. Although locomotor activity decreases at 7 days postexposure, a gradual recovery is observed. Transcriptome analysis indicates alterations in clock genes (Cry2 and Per2) and dopamine‐related genes (NURR1 and tyrosine hydroxylase) in zebrafish larvae. Dietary additive exposure during embryonic development impacts clock genes, influencing dopamine activity and resulting in neurobehavioral changes. This study underscores potential risks associated with dietary additive exposure during critical developmental stages, warranting reconsideration of consumption guidelines, especially for expectant mothers. Observed neurodevelopmental toxicity, even below recommended levels, emphasizes the importance of safeguarding neurodevelopmental health in early life. Our findings contribute to understanding the neurotoxic effects of dietary additives, emphasizing the necessity of protecting neurodevelopment during vulnerable periods. This study is the first to demonstrate a direct correlation between food additives and the dysregulation of key circadian rhythm and dopaminergic genes in zebrafish, providing new insights into the neurodevelopmental impacts of dietary additives. These findings pave the way for further research into the molecular mechanisms and potential implications for human health.

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“…Circadian rhythms have formed a central component of the evolutionary adaptation of all organisms to a variety of environmental conditions, from procaryotes to complex multicellular organisms [221][222][223]. Most organisms experience daily changes in their environment, including light availability, temperature and food.…”

Section: Circadian Rhythm Disruption and Pcosmentioning

confidence: 99%

Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment

Parker

O’Brien

Hawrelak

et al. 2022

IJERPH

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Polycystic ovary syndrome (PCOS) is increasingly recognized as a complex metabolic disorder that manifests in genetically susceptible women following a range of negative exposures to nutritional and environmental factors related to contemporary lifestyle. The hypothesis that PCOS phenotypes are derived from a mismatch between ancient genetic survival mechanisms and modern lifestyle practices is supported by a diversity of research findings. The proposed evolutionary model of the pathogenesis of PCOS incorporates evidence related to evolutionary theory, genetic studies, in utero developmental epigenetic programming, transgenerational inheritance, metabolic features including insulin resistance, obesity and the apparent paradox of lean phenotypes, reproductive effects and subfertility, the impact of the microbiome and dysbiosis, endocrine-disrupting chemical exposure, and the influence of lifestyle factors such as poor-quality diet and physical inactivity. Based on these premises, the diverse lines of research are synthesized into a composite evolutionary model of the pathogenesis of PCOS. It is hoped that this model will assist clinicians and patients to understand the importance of lifestyle interventions in the prevention and management of PCOS and provide a conceptual framework for future research. It is appreciated that this theory represents a synthesis of the current evidence and that it is expected to evolve and change over time.

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Evolutionary conservations, changes of circadian rhythms and their effect on circadian disturbances and therapeutic approaches

Cited by 11 publications

References 300 publications

Identification of potential target genes in Homo sapiens, by miRNA of Triticum aestivum: A cross kingdom computational approach

Identification of potential target genes in Homo sapiens, by miRNA of Triticum aestivum: A cross kingdom computational approach

Impact of food additives on neurodevelopmental processes in zebrafish (Danio rerio): Exploring circadian clock genes and dopamine system

Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment

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