2011
DOI: 10.1111/j.1749-6632.2011.06137.x
|View full text |Cite
|
Sign up to set email alerts
|

Evolutionary–developmental perspectives on immune system interactions among the pregnant woman, placenta, and fetus, and responses to sexually transmitted infectious agents

Abstract: A balance has evolved over deep time between the various immune systems of the "triad" that is linked together for a short period: the pregnant woman, the fetus, and the placenta. This balance is affected by, and helps to determine, the immune responses to maternal infectious agents that may be transmitted to the fetus/infant transplacentally, intrapartum, or via breast milk. This review identifies newer evolutionary concepts and processes related particularly to the human placenta, innate and adaptive immune … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
15
0

Year Published

2012
2012
2024
2024

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 24 publications
(15 citation statements)
references
References 159 publications
(218 reference statements)
0
15
0
Order By: Relevance
“…Mammalian pregnancy represents a unique process during a limited period of time, in which the maternal immune system defies a double challenge: to tolerate the foreign growing fetus and to fight off infections that could affect both mother and fetus [1]. This delicate balance is of special importance when the maternal blood is in direct contact with fetal structures, as it is in mammals.…”
Section: Introductionmentioning
confidence: 99%
“…Mammalian pregnancy represents a unique process during a limited period of time, in which the maternal immune system defies a double challenge: to tolerate the foreign growing fetus and to fight off infections that could affect both mother and fetus [1]. This delicate balance is of special importance when the maternal blood is in direct contact with fetal structures, as it is in mammals.…”
Section: Introductionmentioning
confidence: 99%
“…During pregnancy, the maternal immune system faces a double dilemma: tolerance against growing semi-allogeneic fetus and protection of the mother and the progeny vs. pathogens at the same time. This requires a fine and extremely regulated balance between immune activation and tolerance (36). Yamada et al reported that trophoblast cells in women with recurrent abortion can stimulate peripheral blood mononuclear cells, their proliferation and production of toxic factors for fetus (37).…”
Section: Discussionmentioning
confidence: 99%
“…Various studies have shown that pregnancy disorders such as RSA and preeclampsia are associated with the prevalence of TH17 cells. B-1a lymphocytes are a strong induction for differentiation of TH17 (36,38). Several studies suggest that women with a history of RSA have an abnormal immune response along with an increase in peripheral blood NK and B cells compared with normal control group women (23).…”
Section: Discussionmentioning
confidence: 99%
“…What follows in the rest of this article are some of the core concepts that I try to communicate to the students. There are obviously numerous aspects left out (especially microbiology and infectious disease), but most of the issues have been covered in detail in other writings [23,24,30,48,52,56,57,75,82], including multiple contributions to recent journal special issues [40,56] devoted to the subject of "evolutionary medicine." The reader is referred to these writings and the references therein.…”
Section: Resistance To Introduction Of Evolution Into the Medical Curmentioning
confidence: 99%