Evolutionary dynamics and adaptive analysis of Seneca Valley virus

RNA recombination: non-negligible factor for preventing emergence or reemergence of Senecavirus A

“…Understanding the origin and evolution of SVA is important for its prevention and surveillance. It is speculated that SVA originates from the United States in the 1980s, subsequently spreading to other countries and regions ( 15 ). To date, SVA has evolved into eight distinct lineages, including Clade Ancestor and Clade I to VII ( 16 ).…”

“…Therefore, SVA can rapidly enhance its own adaptive ability via synonymous codon bias evolution ( 18 ). Indeed, the codon preference analysis has indicated that natural selection is a primary driving force that affects the codon usage bias in SVA ( 15 ). Selection pressure analysis has additionally exhibited that the SVA polyprotein has been undergoing selection, with four amino acid residues located in the VP1, 2A, 3C, and 3D encoding regions that are under positive/diversifying selection ( 19 ).…”

Table_8.XLSX

“…It has been still considered as an emerging virus. Natural selection has been a primary evolutionary force affecting SVA codon usage bias (45). Multi-omics analysis provides an integrated approach to facilitate in-depth studies on the virology, especially on the interaction of viruses with their hosts.…”

Image_2.JPEG

“…It has been still considered as an emerging virus. Natural selection has been a primary evolutionary force affecting SVA codon usage bias (45). Multi-omics analysis provides an integrated approach to facilitate in-depth studies on the virology, especially on the interaction of viruses with their hosts.…”