Evolutionary Dynamics and Genomic Impact of Prokaryote Transposable Elements

Do Phages Efficiently Shuttle Transposable Elements Among Prokaryotes?

“…Despite their high prevalence in prokaryotes, IS are not uniformly distributed among genera, or closely related species and strains (Touchon and Rocha 2007; Wagner and De la Chaux 2008; Cordaux et al 2008). Abundant phylogenetic evidence demonstrated that IS distribution, dynamics, and evolution are conditioned by their ability to horizontally transfer between cells (Lawrence et al 1992; Wagner 2006; Wagner and De la Chaux 2008; Cordaux et al 2008; Cerveau et al 2011). Yet, although Tpases can mediate IS mobility within cells, IS lack the genetic material enabling horizontal transfer (HT) between cells.…”

Short- and Long-term Evolutionary Dynamics of Bacterial Insertion Sequences: Insights from Wolbachia Endosymbionts

“…Nevertheless, the evolutionary success of IS families and groups within genomes is highly variable, indicating that horizontal transfer is a necessary but not sufficient condition to IS proliferation. The apparently stochastic loss or success of individual IS families or groups within bacterial strains following import by horizontal transfer may be the result of a complex interplay between various parameters, such as IS intrinsic transpositional efficiency, cellular factors involved in transpositional control, and genomic environment (Chandler and Mahillon 2002; Nagy and Chandler 2004; Cerveau et al 2011). However, such targeted effects can hardly explain a global activation of transposition simultaneously involving multiple IS families and groups.…”

Transposable elements in <i>Escherichia coli</i> antimicrobial resistance

“…Transposable elements are one of the major forces that drive prokaryote genome evolution. Analyses of TE evolutionary dynamics revealed extensive variability in TE density between prokaryote genomes, even closely related [10]. To explain this variability, a model of recurrent invasion/proliferation/extinction cycles has been proposed by Cerveau et al [10], wherein they examined different parameters that influence these cycles in two of the simplest TE classes: insertion sequences and group II introns.…”

“…Analyses of TE evolutionary dynamics revealed extensive variability in TE density between prokaryote genomes, even closely related [10]. To explain this variability, a model of recurrent invasion/proliferation/extinction cycles has been proposed by Cerveau et al [10], wherein they examined different parameters that influence these cycles in two of the simplest TE classes: insertion sequences and group II introns. In particular, they have focused on TE trans- position efficiency (mechanisms and regulation), ability to transfer horizontally (through plasmids and phages), and impact on genome evolution (gene activation/inactivation and structural variation).…”