Evolutionary dynamics of endogenous feline leukemia virus proliferation among species of the domestic cat lineage

Polani, Sagi; Roca, Alfred L.; Rosensteel, Bryan B.; Kolokotronis, Sergios‐Orestis; Bar‐Gal, Gila Kahila

doi:10.1016/j.virol.2010.06.010

Cited by 39 publications

(49 citation statements)

References 46 publications

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“…Studies on endogenous feline leukemia viruses in the germ lines of the domestic cat and related wild species of the genus Felis revealed similar results to those describe in the current study, suggesting a complex history of interactions between FeLV and the germ lines of the species that comprise the domestic cat lineage (Polani et al, 2010). These findings are also analogous to the different patterns seen across species of primates in studies involving ERVs also found in humans (Bannert and Kurth, 2006).…”

Section: Evolutionary Dynamics Of Enjsrvssupporting

confidence: 87%

Evolutionary dynamics of endogenous Jaagsiekte sheep retroviruses proliferation in the domestic sheep, mouflon and Pyrenean chamois

Sistiaga-Poveda

Jugo

2014

Heredity

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The oncogenic exogenous Jaagsiekte sheep retrovirus (JSRV), responsible for ovine pulmonary adenocarcinoma, has several endogenous counterparts termed enJSRVs. Although many of these elements have been inactivated over time by the accumulation of deleterious mutations or internal recombination leading to solo long terminal repeat (LTR) formation, several members of enJSRVs have been identified as nearly intact and probably represent recent integration events. To determine the level of enJSRV polymorphism in the sheep population and related species, we have undertaken a study by characterizing enJSRVs copies and independent integration sites in six domestic sheep and two wild species of the sheep lineage. enJSRVs copies were detected by amplifying the env-LTR region by PCR, and for the detection of the insertion sites, we used two approaches: (1) an in silico approach based on the recently published Sheep Reference Genome Assembly (OARv3.0) and (2) an experimental approach based on PCR suppression and inverse PCR techniques. In total, 103 enJSRV sequences were generated across 10 individuals and enJSRV integrations were found on 11 of the 28 sheep chromosomes. These findings suggest that there are still uncharacterized enJSRVs, and that some of the integration sites are variable among the different species, breeds of the same species, subspecies and geographic locations.

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Section: Evolutionary Dynamics Of Enjsrvssupporting

confidence: 87%

Evolutionary dynamics of endogenous Jaagsiekte sheep retroviruses proliferation in the domestic sheep, mouflon and Pyrenean chamois

Sistiaga-Poveda

Jugo

2014

Heredity

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“…In a study on the endogenous form of feline leukemia virus (enFeLV), which is a Gammaretrovirus , domestic and wild cats were analyzed to detect env-LTR and LTR sequences of enFeLVs [34]. No evident differences in the presence of enFeLVs were observed between domestic cat and its similar wild relatives [34].…”

Section: Presence Of Ervs In Domestic Animalsmentioning

confidence: 99%

“…No evident differences in the presence of enFeLVs were observed between domestic cat and its similar wild relatives [34]. In addition, the sequences of enFeLVs from the domestic cat and its nearest wildcat species ( F. silvestris and F. lybica ) clustered together; therefore, it seems that these copies were present before cat domestication and that there has not been any substantial activity since then [34]. …”

Section: Presence Of Ervs In Domestic Animalsmentioning

confidence: 99%

Endogenous Retroviruses in Domestic Animals

Garcia-Etxebarria

Sistiaga-Poveda

Jugo

2014

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Endogenous retroviruses (ERVs) are genomic elements that are present in a wide range of vertebrates. Although the study of ERVs has been carried out mainly in humans and model organisms, recently, domestic animals have become important, and some species have begun to be analyzed to gain further insight into ERVs. Due to the availability of complete genomes and the development of new computer tools, ERVs can now be analyzed from a genome-wide viewpoint. In addition, more experimental work is being carried out to analyze the distribution, expression and interplay of ERVs within a host genome. Cats, cattle, chicken, dogs, horses, pigs and sheep have been scrutinized in this manner, all of which are interesting species in health and economic terms. Furthermore, several studies have noted differences in the number of endogenous retroviruses and in the variability of these elements among different breeds, as well as their expression in different tissues and the effects of their locations, which, in some cases, are near genes. These findings suggest a complex, intriguing relationship between ERVs and host genomes. In this review, we summarize the most important in silico and experimental findings, discuss their implications and attempt to predict future directions for the study of these genomic elements.

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“…The endogenous counterparts of exogenous FeLV, termed enFeLVs, are integrated into the genomes of the Felis genus. Primary colonization of the feline germ line by FeLVs is believed to have occurred in an ancestor of the domestic cat after separation from the leopard lineage (2,11,31). Like most endogenous retroviruses, enFeLVs are noninfectious and nonpathogenic (4).…”

mentioning

confidence: 99%

Infectious Endogenous Retroviruses in Cats and Emergence of Recombinant Viruses

Anai

Ochi

Watanabe

et al. 2012

J Virol

189

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bEndogenous retroviruses (ERVs) comprise a significant percentage of the mammalian genome, and it is poorly understood whether they will remain as inactive genomes or emerge as infectious retroviruses. Although several types of ERVs are present in domestic cats, infectious ERVs have not been demonstrated. Here, we report a previously uncharacterized class of endogenous gammaretroviruses, termed ERV-DCs, that is present and hereditary in the domestic cat genome. We have characterized a subset of ERV-DC proviral clones, which are numbered according to their genomic insertions. One of these, ERV-DC10, located in the q12-q21 region on chromosome C1, is an infectious gammaretrovirus capable of infecting a broad range of cells, including human. Our studies indicate that ERV-DC10 entered the genome of domestic cats in the recent past and appeared to translocate to or reintegrate at a distinct locus as infectious ERV-DC18. Insertional polymorphism analysis revealed that 92 of 244 domestic cats had ERV-DC10 on a homozygous or heterozygous locus. ERV-DC-like sequences were found in primate and rodent genomes, suggesting that these ERVs, and recombinant viruses such as RD-114 and BaEV, originated from an ancestor of ERV-DC. We also found that a novel recombinant virus, feline leukemia virus subgroup D (FeLV-D), was generated by ERV-DC env transduction into feline leukemia virus in domestic cats. Our results indicate that ERV-DCs behave as donors and/or acceptors in the generation of infectious, recombinant viruses. The presence of such infectious endogenous retroviruses, which could be harmful or beneficial to the host, may affect veterinary medicine and public health.

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Evolutionary dynamics of endogenous feline leukemia virus proliferation among species of the domestic cat lineage

Cited by 39 publications

References 46 publications

Evolutionary dynamics of endogenous Jaagsiekte sheep retroviruses proliferation in the domestic sheep, mouflon and Pyrenean chamois

Evolutionary dynamics of endogenous Jaagsiekte sheep retroviruses proliferation in the domestic sheep, mouflon and Pyrenean chamois

Endogenous Retroviruses in Domestic Animals

Infectious Endogenous Retroviruses in Cats and Emergence of Recombinant Viruses

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