Evolutionary dynamics of foot-and-mouth disease virus O/ME-SA/Ind2001 lineage

Subramaniam, Saravanan; Mohapatra, Jajati K.; Sharma, Gaurav Kumar; Biswal, Jitendra K.; Ranjan, Rajeev; Rout, Manoranjan; Das, Biswajit; Dash, Biswajit; Sanyal, Aniket; Pattnaik, Bramhadev

doi:10.1016/j.vetmic.2015.05.015

Cited by 41 publications

(58 citation statements)

References 24 publications

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“…The mean substitution rate computed for the Ind-2001 lineage was 5.02 x10 -3 (95% HPD = 3.83x10 -3 , 6.25x10 -3 ) substitutions per site per year in the VP1 protein-coding region, similar to previous estimates of Ind-2001 and PanAsia lineages estimates [12, 27]. …”

Section: Resultssupporting

confidence: 85%

“…Antigenic characterization of viruses of this lineage has predicted sufficient cross-reactivity with the antigen O/IND/R2/75 currently used in the Indian vaccines [12, 33]. However, antigenic matching of recently detected O/ME-SA/Ind-2001 viruses to viruses used for vaccine production for use in Southeast Asia is critical to ensure adequate protection.…”

Section: Discussionmentioning

confidence: 99%

“…The O/ME-SA/Ind-2001 lineage of FMDV was detected and first defined in 2001 [11] and has become the dominant lineage of serotype O within the Indian subcontinent since 2008 [12]. Other FMDV strains collected before the initial characterization of the lineage (between 1995–2002) in Jordan, Israel, Bahrain, Kuwait, Saudi Arabia, the United Arab Emirates (UAE), Oman, and the Palestinian Autonomous Territories were later classified within the Ind-2001 lineage [13].…”

Section: Introductionmentioning

confidence: 99%

“…All outbreaks outside of the Indian subcontinent that have involved the O/ME-SA/Ind-2001 lineage since 2013 have been caused by the sublineage Ind-2001d [12]. In 2015, this lineage was detected for the first time in Southeast Asia in cases reported from Vietnam and Laos [17].…”

Section: Introductionmentioning

confidence: 99%

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First detection of foot-and-mouth disease virus O/Ind-2001d in Vietnam

Long

Brito

et al. 2017

PLoS ONE

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In recent years, foot-and-mouth disease virus (FMDV) serotype O, topotype Middle East-South Asia (ME-SA), lineage Ind-2001d has spread from the Indian subcontinent to the Middle East, North Africa, and Southeast Asia. In the current report, we describe the first detection of this lineage in Vietnam in May, 2015 in Đắk Nông province. Three subsequent outbreaks caused by genetically related viruses occurred between May–October, 2015 after which the virus was not detected in clinical outbreaks for at least 15 subsequent months. The observed outbreaks affected (in chronological order): cattle in Đắk Nông province, pigs in Đắk Lắk province and Đắk Nông province, and cattle in Ninh Thuận province. The clinical syndromes associated with these outbreaks were consistent with typical FMD in the affected species. Overall attack rate on affected premises was 0.85 in pigs and 0.93 in cattle over the course of the outbreak. Amongst 378 pigs at risk on affected premises, 85 pigs died during the outbreaks; there were no deaths among cattle. The manner in which FMDV/O/ME-SA/Ind-2001d was introduced into Vietnam remains undetermined; however, movement of live cattle is the suspected route. This incursion has substantial implications for epidemiology and control of FMD in Southeast Asia.

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Section: Resultssupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

First detection of foot-and-mouth disease virus O/Ind-2001d in Vietnam

Long

Brito

et al. 2017

PLoS ONE

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“…However, the rate estimated for this study was higher than those computed across other serotype O viruses estimated at 6.65 × 10 −3 [39], 6.34 × 10 −3 [40], or 4.81 × 10 −3 (serotype O collected globally between 1939 and 2010) [41] substitutions/site/year. The high mutation rate found in our analyses may be a result of capturing mutations that do not become fixed in a population, as a consequence of sampling a high number of outbreaks in a relatively short period of time.…”

Section: Discussioncontrasting

confidence: 70%

Phylodynamics of foot-and-mouth disease virus O/PanAsia in Vietnam 2010–2014

Brito

Pauszek

Eschbaumer

et al. 2017

Vet Res

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Foot-and-mouth disease virus (FMDV) is endemic in Vietnam, a country that plays an important role in livestock trade within Southeast Asia. The large populations of FMDV-susceptible species in Vietnam are important components of food production and of the national livelihood. In this study, we investigated the phylogeny of FMDV O/PanAsia in Vietnam, reconstructing the virus’ ancestral host species (pig, cattle or buffalo), clinical stage (subclinical carrier or clinically affected) and geographical location. Phylogenetic divergence time estimation and character state reconstruction analyses suggest that movement of viruses between species differ. While inferred transmissions from cattle to buffalo and pigs and from pigs to cattle are well supported, transmission from buffalo to other species, and from pigs to buffalo may be less frequent. Geographical movements of FMDV O/PanAsia virus appears to occur in all directions within the country, with the South Central Coast and the Northeast regions playing a more important role in FMDV O/PanAsia spread. Genetic selection of variants with changes at specific sites within FMDV VP1 coding region was different depending on host groups analyzed. The overall ratio of non-synonymous to synonymous nucleotide changes was greater in pigs compared to cattle and buffalo, whereas a higher number of individual amino acid sites under positive selection were detected in persistently infected, subclinical animals compared to viruses collected from clinically diseased animals. These results provide novel insights to understand FMDV evolution and its association with viral spread within endemic countries. These findings may support animal health organizations in their endeavor to design animal disease control strategies in response to outbreaks.Electronic supplementary materialThe online version of this article (doi:10.1186/s13567-017-0424-7) contains supplementary material, which is available to authorized users.

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Antigenic variability of foot-and-mouth disease virus serotype O during serial cytolytic passage

et al. 2017

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The emergence and disappearance of antigenic variants of foot-and-mouth disease virus (FMDV) during a field outbreak occurs periodically due to the volatile nature of its genome. In the present analysis, change in antigenic behavior of serotype O FMDV during the serial cytolytic passage in the absence of immune pressure was observed. Initially, the isolate showed a poor antigenic match (relationship value <0.3) with the serotype O vaccine strain and upon serial passage increase in relationship value was observed. Comparison of capsid sequence revealed substitution at four positions (VP3:K → E and P → S, VP1:E → K and R → Q) acquired during the serial passage. Examination of passage level and amino acid substitution revealed the critical role of position VP3-58 that was identified earlier as crucial for antigenic site IV, in the observed antigenic variability. The role of position VP3-58 was further confirmed using reverse genetics approach.

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Evolutionary dynamics of foot-and-mouth disease virus O/ME-SA/Ind2001 lineage

Cited by 41 publications

References 24 publications

First detection of foot-and-mouth disease virus O/Ind-2001d in Vietnam

First detection of foot-and-mouth disease virus O/Ind-2001d in Vietnam

Phylodynamics of foot-and-mouth disease virus O/PanAsia in Vietnam 2010–2014

Antigenic variability of foot-and-mouth disease virus serotype O during serial cytolytic passage

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