Evolutionary Engineering of Microorganisms to Overcome Toxicity During Lignocellulose Hydrolysates Utilization

Lastiri-Pancardo, Gustavo; Utrilla, José

doi:10.1007/978-3-319-51729-2_7

Cited by 2 publications

(2 citation statements)

References 94 publications

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“…These mutations enable the adapted cell to move back towards the pre-inhibited physiological state. Specific tolerance responses have been shown to be more energy efficient than global stress responses ( Lastiri-Pancardo and Utrilla, 2017 ). In contrast, ALE control experiments of the BS168 xyl and KO7s xyl backgrounds displayed a more constant increase in growth rate ( Fig.…”

Section: Resultsmentioning

confidence: 99%

“…The development of microbial strains with increased tolerance has the potential to minimize the degree of detoxification required. Unfortunately, tolerance is a complex trait, involving the coordinated action of hundreds of genes ( Lastiri-Pancardo and Utrilla, 2017 ). As biomass hydrolysates contain a plethora of different toxic compounds, rational design is challenging due to the lack of prerequisite knowledge.…”

Section: Introductionmentioning

confidence: 99%

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Adaptive laboratory evolution of Bacillus subtilis to overcome toxicity of lignocellulosic hydrolysate derived from Distiller's dried grains with solubles (DDGS)

Driessen

Johnsen

Pogrebnyakov

et al. 2023

Metabolic Engineering Communications

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Adaptive laboratory evolution of Bacillus subtilis to overcome toxicity of lignocellulosic hydrolysate derived from Distiller's dried grains with solubles (DDGS)

Driessen

Johnsen

Pogrebnyakov

et al. 2023

Metabolic Engineering Communications

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Bioremediation through microbes: systems biology and metabolic engineering approach

Dangi

Sharma

Hill

et al. 2018

Critical Reviews in Biotechnology

248

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Today, environmental pollution is a serious problem, and bioremediation can play an important role in cleaning contaminated sites. Remediation strategies, such as chemical and physical approaches, are not enough to mitigate pollution problems because of the continuous generation of novel recalcitrant pollutants due to anthropogenic activities. Bioremediation using microbes is an eco-friendly and socially acceptable alternative to conventional remediation approaches. Many microbes with a bioremediation potential have been isolated and characterized but, in many cases, cannot completely degrade the targeted pollutant or are ineffective in situations with mixed wastes. This review envisages advances in systems biology (SB), which enables the analysis of microbial behavior at a community level under different environmental stresses. By applying a SB approach, crucial preliminary information can be obtained for metabolic engineering (ME) of microbes for their enhanced bioremediation capabilities. This review also highlights the integrated SB and ME tools and techniques for bioremediation purposes.

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Evolutionary Engineering of Microorganisms to Overcome Toxicity During Lignocellulose Hydrolysates Utilization

Cited by 2 publications

References 94 publications

Adaptive laboratory evolution of Bacillus subtilis to overcome toxicity of lignocellulosic hydrolysate derived from Distiller's dried grains with solubles (DDGS)

Adaptive laboratory evolution of Bacillus subtilis to overcome toxicity of lignocellulosic hydrolysate derived from Distiller's dried grains with solubles (DDGS)

Bioremediation through microbes: systems biology and metabolic engineering approach

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