Evolutionary game theory: cells as players

Hummert, Sabine; Bohl, Katrin; Basanta, David; Deutsch, Andreas; Werner, Sarah; Theißen, Günter; Schroeter, Anja; Schuster, Stefan

doi:10.1039/c3mb70602h

Cited by 135 publications

(137 citation statements)

References 190 publications

(285 reference statements)

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“…Game theory has been used to analyse problems in cell and molecular biology with a broad range of objectives such as understanding metabolic processes, including the production of costly public goods by cells or cross-feeding, or analysing different competition and interaction models between cellular populations (Hummert et al, 2014). …”

Section: Game's Equilibrium and Discussionmentioning

confidence: 99%

Economic Game Theory to Model the Attenuation of Virulence of an Obligate Intracellular Bacterium

Tago

Meyer

2016

Front. Cell. Infect. Microbiol.

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Diseases induced by obligate intracellular pathogens have a large burden on global human and animal health. Understanding the factors involved in the virulence and fitness of these pathogens contributes to the development of control strategies against these diseases. Based on biological observations, a theoretical model using game theory is proposed to explain how obligate intracellular bacteria interact with their host. The equilibrium in such a game shows that the virulence and fitness of the bacterium is host-triggered and by changing the host's defense system to which the bacterium is confronted, an evolutionary process leads to an attenuated strain. Although, the attenuation procedure has already been conducted in practice in order to develop an attenuated vaccine (e.g., with Ehrlichia ruminantium), there was a lack of understanding of the theoretical basis behind this process. Our work provides a model to better comprehend the existence of different phenotypes and some underlying evolutionary mechanisms for the virulence of obligate intracellular bacteria.

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Section: Game's Equilibrium and Discussionmentioning

confidence: 99%

Economic Game Theory to Model the Attenuation of Virulence of an Obligate Intracellular Bacterium

Tago

Meyer

2016

Front. Cell. Infect. Microbiol.

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“…EGT models have proved successful to analyse various cell interactions by formulating appropriate games [171,172]. Basanta et al [22] developed an EGT model to investigate the impact of interactions between different glioma cell phenotypes with increasing degree of malignancy on malignant progression.…”

Section: Malignant Progressionmentioning

confidence: 99%

The biology and mathematical modelling of glioma invasion: a review

Alfonso

Talkenberger

Seifert

et al. 2017

J. R. Soc. Interface.

188

163

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Adult gliomas are aggressive brain tumours associated with low patient survival rates and limited life expectancy. The most important hallmark of this type of tumour is its invasive behaviour, characterized by a markedly phenotypic plasticity, infiltrative tumour morphologies and the ability of malignant progression from low-to high-grade tumour types. Indeed, the widespread infiltration of healthy brain tissue by glioma cells is largely responsible for poor prognosis and the difficulty of finding curative therapies. Meanwhile, mathematical models have been established to analyse potential mechanisms of glioma invasion. In this review, we start with a brief introduction to current biological knowledge about glioma invasion, and then critically review and highlight future challenges for mathematical models of glioma invasion.

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“…[5]. Such games could possibly be applied to study cooperative and noncooperative behavior in economics [14].…”

Section: Discussionmentioning

confidence: 99%

Evolutionary Coalitional Games

Płatkowski

2015

Dyn Games Appl

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We introduce the concept of evolutionary coalitional games played in a large population. The members of the population play a strategy chosen from a finite set and interact in randomly formed coalitions. The interactions are described by a multiplayer strategic game. Each coalition generates a total utility, identified with the value of the coalition, and equal to the sum of the payoffs of its all members from the multiplayer game. The total utility is distributed among the coalition members, proportionally to their Shapley values. Evolution of the whole population is governed by the replicator equations. Polymorphic stationary states of the population are studied for various types of the multiplayer social dilemma games. It is argued that application of coalitional game theory solution concepts to social dilemma models of evolutionary game theory can foster cooperation in the long run.

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Evolutionary game theory: cells as players

Cited by 135 publications

References 190 publications

Economic Game Theory to Model the Attenuation of Virulence of an Obligate Intracellular Bacterium

Economic Game Theory to Model the Attenuation of Virulence of an Obligate Intracellular Bacterium

The biology and mathematical modelling of glioma invasion: a review

Evolutionary Coalitional Games

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