“…In the case of mutations, it is the main process used by all the viruses, being the mutation rate very high, mainly in viruses with an RNA genome. The nucleotide substitution rates estimated for some of the viruses included in this review are: 1.39 × 10 −3 substitution per site per year (s/s/y) for BCoV [53], 1.58 × 10 −2 s/s/y for BKV [131], 4.27 × 10 −4 s/s/y for bovine astrovirus (associated with encephalitis) [99], 2.78 × 10 −3 s/s/y-3.81 × 10 −3 for BoNoV [176,177], 1.40 × 10 −2 s/s/y for BEV [178], 1.14 × 10 −2 s/s/y for SBV [179], 3 × 10 −3 s/s/y for BToV [180], and 5.90 × 10 −4 -9.3 × 10 −3 for bovine pestivirus [122,181,182].…”