Evolutionary molecular medicine

Nesse, Randolph M.; Ganten, Detlev; Gregory, T. Ryan; Omenn, Gilbert S.

doi:10.1007/s00109-012-0889-9

Cited by 52 publications

(51 citation statements)

References 106 publications

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“…Importantly, the success of individual ribozymes also depended to a large degree on functional interactions with other cellular RNAs (today: gene products), namely, the (genetic) background of the protocell (Brosius 2003c). In contemporary biology and medicine, considerations of interactions of various alleles within the genomic background, as well as individual variability of gene expression levels including complete gene depletions, are beginning to gain wider acceptance (Williams and Nesse 1991;Sibilia and Wagner 1995;Brosius 2003b;Ganten and Nesse 2012;Nesse et al 2012).…”

Section: Most Evolutionary Principles Are At Least As Ancient As the mentioning

confidence: 99%

The Persistent Contributions of RNA to Eukaryotic Gen(om)e Architecture and Cellular Function

Brosius

2014

Cold Spring Harbor Perspectives in Biology

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Section: Most Evolutionary Principles Are At Least As Ancient As the mentioning

confidence: 99%

The Persistent Contributions of RNA to Eukaryotic Gen(om)e Architecture and Cellular Function

Brosius

2014

Cold Spring Harbor Perspectives in Biology

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“…The corresponding 99.6% failure rate indicates that the mechanisms underlying the development of ADs remain poorly understood. A fundamental difficulty in elucidating the genetics of AD and other complex age‐related diseases characteristic of postreproductive life is the undefined role of evolution in establishing the disease mechanisms (Nesse, Ganten, Gregory & Omenn, 2012). This problem is complicated by recent changes in human life expectancy (Oeppen & Vaupel, 2002) and the fitness landscape (Corella & Ordovas, 2014; Crespi, Stead & Elliot, 2010; Kulminski, 2013; Vijg & Suh, 2005).…”

Section: Introductionmentioning

confidence: 99%

Apolipoprotein E region molecular signatures of Alzheimer's disease

et al. 2018

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SummaryAlthough the APOE region is the strongest genetic risk factor for Alzheimer's diseases (ADs), its pathogenic role remains poorly understood. Elucidating genetic predisposition to ADs, a subset of age‐related diseases characteristic for postreproductive period, is hampered by the undefined role of evolution in establishing molecular mechanisms of such diseases. This uncertainty is inevitable source of natural‐selection–free genetic heterogeneity in predisposition to ADs. We performed first large‐scale analysis of linkage disequilibrium (LD) structures characterized by 30 polymorphisms from five genes in the APOE 19q13.3 region (BCAM,NECTIN2,TOMM40,APOE, and APOC1) in 2,673 AD‐affected and 16,246 unaffected individuals from five cohorts. Consistent with the undefined role of evolution in age‐related diseases, we found that these structures, being highly heterogeneous, are significantly different in subjects with and without ADs. The pattern of the difference represents molecular signature of AD comprised of single nucleotide polymorphisms (SNPs) from all five genes in the APOE region. Significant differences in LD in subjects with and without ADs indicate SNPs from different genes likely involved in AD pathogenesis. Significant and highly heterogeneous molecular signatures of ADs provide unprecedented insight into complex polygenetic predisposition to ADs in the APOE region. These findings are more consistent with a complex haplotype than with a single genetic variant origin of ADs in this region.

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“…This dynamic and extremely complex interaction of human cultural activities on the genes (mutations) and their expression ("epigenetics") is the basis of the "collision" of our slow biological evolution and our rapid and quixotic cultural evolution that is affecting the human disease patterns we are witnessing today, as well as the overall eco-system alteration. Emerging out of this awareness is the new paradigm of "Evolutionary Molecular Medicine" (Nesse et al 2012).…”

Section: Global Bioethics As It Relates To "One Health One Planet"mentioning

confidence: 99%

Global Bioethical Prevention of the Collision of Biological and Cultural Evolution on Miserable Human Survival

Troskoa¹

2015

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With the cultural myth that science can only determine the way the world "is" (facts), while humanities, social sciences, lawyers, philosophers, and theologians must determine the way the world "ought to be" (values), those in position of global-, national-, and local-political power make major decisions of the use (or non-use) of scientific knowledge and technology. As a result, the human being has created a non-scientifically based cultural environment that is affecting his ability to survive. In effect, cultural evolution is occurring more rapidly than biological evolution that can adapt to the changes brought about in the physical and psycho-social environments. In a pluralistic cultural world, where each society has generated a different view of human nature and different ethical values, the use, misuse, or non-use of scientific and technological advances are derived from these unscientific views of human nature. Since all life depends on limiting interacting environmental and ecological factors, it is imperative that scientific information be used to govern how to minimize irreversible effects on life-sustaining ecological factors, but also scientific information bearing on understanding human nature ought to be integrated into a "global bioethics". While ethical values cannot be directly derived from scientific factors, it is also true that human values or our "ought" cannot be maintained in ignorance or defiance of the facts or the "is".

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Evolutionary molecular medicine

Cited by 52 publications

References 106 publications

The Persistent Contributions of RNA to Eukaryotic Gen(om)e Architecture and Cellular Function

The Persistent Contributions of RNA to Eukaryotic Gen(om)e Architecture and Cellular Function

Apolipoprotein E region molecular signatures of Alzheimer's disease

Global Bioethical Prevention of the Collision of Biological and Cultural Evolution on Miserable Human Survival

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