Evolutionary relationship of the L- and M-class genome segments of bat-borne fusogenic orthoreoviruses in Malaysia and Australia

Voon, Kenny; Chua, Kaw Bing; Yu, Meng; Crameri, Gary; Barr, Jennifer; Malik, Yasmin A; Wang, Lin‐Fa

doi:10.1099/vir.0.033498-0

Cited by 29 publications

(47 citation statements)

References 30 publications

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“…3A), and furthermore place python RRV in a subclade with both BRV and Broome virus (BroV), a recent megachiropteran/pteropine (megabat/fruit bat, flying fox) isolate that is the prototype strain of a tentative new Orthoreovirus species (“Broome orthoreovirus”) [46], as has been previously reported [23], [46]. Other pteropine isolates, as well as their zoonotic relatives obtained from humans with respiratory disease, constitute species Nelson Bay orthoreovirus [22], [47], whereas microchiropteran/vespertilionid (microbat/insectivorous bat, evening bat) isolates to date are members of species Mammalian orthoreovirus [48].…”

Section: Resultsmentioning

confidence: 70%

Bioinformatics of Recent Aqua- and Orthoreovirus Isolates from Fish: Evolutionary Gain or Loss of FAST and Fiber Proteins and Taxonomic Implications

Nibert

Duncan

2013

PLoS ONE

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Family Reoviridae, subfamily Spinareovirinae, includes nine current genera. Two of these genera, Aquareovirus and Orthoreovirus, comprise members that are closely related and consistently share nine homologous proteins. Orthoreoviruses have 10 dsRNA genome segments and infect reptiles, birds, and mammals, whereas aquareoviruses have 11 dsRNA genome segments and infect fish. Recently, the first 10-segmented fish reovirus, piscine reovirus (PRV), has been identified and shown to be phylogenetically divergent from the 11-segmented viruses constituting genus Aquareovirus. We have recently extended results for PRV by showing that it does not encode a fusion-associated small transmembrane (FAST) protein, but does encode an outer-fiber protein containing a long N-terminal region of predicted α-helical coiled coil. Three recently characterized 11-segmented fish reoviruses, obtained from grass carp in China and sequenced in full, are also divergent from the viruses now constituting genus Aquareovirus, though not to the same extent as PRV. In the current study, we reexamined the sequences of these three recent isolates of grass carp reovirus (GCRV)–HZ08, GD108, and 104–for further clues to their evolution relative to other aqua- and orthoreoviruses. Structure-based fiber motifs in their encoded outer-fiber proteins were characterized, and other bioinformatics analyses provided evidence against the presence of a FAST protein among their encoded nonstructural proteins. Phylogenetic comparisons showed the combination of more distally branching, approved Aquareovirus and Orthoreovirus members, plus more basally branching isolates GCRV104, GCRV-HZ08/GD108, and PRV, constituting a larger, monophyletic taxon not suitably recognized by the current taxonomic hierarchy. Phylogenetics also suggested that the last common ancestor of all these viruses was a fiber-encoding, nonfusogenic virus and that the FAST protein family arose from at least two separate gain-of-function events. In addition, an apparent evolutionary correlation was found between the gain or loss of NS-FAST and outer-fiber proteins among more distally branching members of this taxon.

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Section: Resultsmentioning

confidence: 70%

Bioinformatics of Recent Aqua- and Orthoreovirus Isolates from Fish: Evolutionary Gain or Loss of FAST and Fiber Proteins and Taxonomic Implications

Nibert

Duncan

2013

PLoS ONE

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“…Over the past few years, the isolation of novel respiratory tract infectious agents, specifically those of family Reoviridae , subfamily Spinareovirinae , genus Orthoreovirus , species Pteropine orthoreovirus (PRV) [Chua et al, , , ; Cheng et al, ; Voon et al, ; Wong et al, ; Yamanaka et al, ], which show close genetic relationship to bat‐borne orthoreoviruses [Gard and Marshall, ; Pritchard et al, ; Du et al, ; Thalmann et al, ; Voon et al, ; Hu et al, ; Lorusso et al, ]; among human beings living in or travelling to Southeast Asia specifically Malaysia and Indonesia suggests the potential of continuous spill‐over events into human populations [Chua et al, , , ; Cheng et al, ; Wong et al, ; Yamanaka et al, ]. Although, there is no direct evidence of bat origin in these human cases, the risk factor of exposure to bats before the onset of disease suggests otherwise [Chua et al, , ; Wong et al, ; Yamanaka et al, 2014].…”

Section: Introductionmentioning

confidence: 99%

Serological evidence of human infection with Pteropine orthoreovirus in Central Vietnam

et al. 2015

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Pteropine orthoreovirus, potentially of bat origin, has been reported to cause respiratory tract infections among human beings in Southeast Asia. Twelve IgG ELISA‐positive cases with antibodies against Pteropine orthoreovirus were detected among 272 human serum samples collected between March and June 2014 from in and around Hue City, Central Vietnam. These 12 cases were IgM ELISA negative. Neutralizing antibodies were also detected among six of these cases with the highest titer of 1:1,280 in 2 cases (both female, 32 and 68 years old, respectively). This is the first report of human infection with Pteropine orthoreovirus in Central Vietnam. These findings indicate the need for surveillance on Pteropine orthoreovirus infections in Southeast Asia to enable prevention and control strategies to be developed should a change in virulence occur. J. Med. Virol. 87:2145–2148, 2015. © 2015 The Authors. Journal of Medical Virology Wiley Periodicals, Inc.

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“…Under the group of double-stranded ribonucleic acid (RNA) viruses, there is a family of viruses known as Reoviridae, to which PRV belongs [2]. Reovirus is also known as respiratory enteric orphan virus, since it was not known to cause any illness when it was first discovered [1]. Under Reoviridae, there are a few genera; the genus of interest in the present work is Orthoreovirus (Table 1).…”

Section: Introductionmentioning

confidence: 99%

“…The name was changed from Nelson Bay to Pteropine (referring to fruit bats of the Pteropus spp., e.g., Pteropus poliocephalus, Pteropus hypomelanus, and Pteropus vampyrus) to reflect the reservoir hosts carrying the virus [1]. Meanwhile, the name NBV is referred to as the prototype isolate of PRV.…”

Section: Introductionmentioning

confidence: 99%

Pteropine orthoreovirus: An important emerging virus causing infectious disease in the tropics?

Tan

Teng

Chua

et al. 2017

J Infect Dev Ctries

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Introduction: Pteropine orthoreovirus (PRV) is an emerging zoonotic respiratory virus that has spilled over from bats to humans. Though initially found only in bats, further case studies have found viable virus in ill patients. Methodology: PubMed was queried with the keywords of Nelson Bay orthoreovirus OR Pteropine orthoreovirus OR Melaka orthoreovirus OR Kampar orthoreovirus, and returned 17 hits. Results: Based on prevalence studies, the presence of PRV has been reported in Malaysia and Vietnam, both developing countries. Other case reports also provide further evidence of the presence of PRV in the Southeast Asian region. Despite the absence of PRV in their home countries, travellers from Hong Kong and Japan to Indonesia have returned to their countries ill with this virus, indicating that local communities in Indonesia might be affected by this virus. Conclusions: This work aims to bring to light this emerging zoonotic respiratory virus circulating among developing countries in Southeast Asia. To improve the understanding of PRV of the medical and scientific community in the Southeast Asian region, this work introduces the general features of PRV, reports of imported PRV, prevalence, and clinical features of PRV. Gaps in knowledge about PRV have also been identified in this work, and we hope that future studies can be undertaken to improve our understanding of this virus.

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Evolutionary relationship of the L- and M-class genome segments of bat-borne fusogenic orthoreoviruses in Malaysia and Australia

Cited by 29 publications

References 30 publications

Bioinformatics of Recent Aqua- and Orthoreovirus Isolates from Fish: Evolutionary Gain or Loss of FAST and Fiber Proteins and Taxonomic Implications

Bioinformatics of Recent Aqua- and Orthoreovirus Isolates from Fish: Evolutionary Gain or Loss of FAST and Fiber Proteins and Taxonomic Implications

Serological evidence of human infection with Pteropine orthoreovirus in Central Vietnam

Pteropine orthoreovirus: An important emerging virus causing infectious disease in the tropics?

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