Evolutionary stability of transspecies major histocompatibility complex class II DRB lineages in humans and rhesus monkeys

Molecular characterization of expressed DQA and DQB genes in the California sea lion ( Zalophus californianus )

“…This confirms findings in other pinniped species (Slade 1992), but contrasts sharply with the corresponding himian and canine DQ genes (Robinson 2001;Polvi et al 1997;Wagner et al, 1998Wagner et al, , 1999. The disparity between the extent and distribution of sequence heterogeneity between the sea lion and the domestic dog, the closest relative with an extensively characterized MHC (Schreiber et al 1998;Wagner et al 1999), is particu-larly significant because it contradicts the well-established concept of shared residues and motifs within and between species Erlich and Gyllensten 1991;Fan et al 1989;Gustafsson et al 1990;Kupfermann et al 1992;Slierendregt et al 1992;Yaeger and Hughes 1999). In combination, these findings may indicate an independent (convergent) evolution associated with pathogen differences between the marine and terrestrial environments, or may bring into fiirther question the concept of common ancestral lineages between marine and terrestrial carnivores.…”

“…This is the first study characterizing near-full-and full-length (DQB and DQA, respectively) MHC class n gene sequences in a marine mammal species. These genes were selected because trans-species conservation of class II MHC sequences has been shown in other mammals Erlich and Gyllensten 1991;Fan 1989;Gustafsson et al 1990; Kupfermann et al 1992;Slierendregt et al 1992;Yaeger and Hughes 1999). While there is limited information regarding the MHC of species closely related to the California sea lion (order/suborder Camivora/Caniformia/ Pinnipedia) (McKenna and Bell 1997), the class II MHC genes of a related terrestrial carnivore, the domestic dog (order/suborder Camivora/Caniformia/Canidae); Schreiber et al 1998), have been extensively studied (Polvi et al 1997;Sarmiento et al 1992Sarmiento et al , 1993Wagner et al 1996Wagner et al , 1998Wagner et al , 1999.…”

Trans-species polymorphism of class IIMhc loci in danio fishes

“…Molecular evidence for the allelic lineages predating the divergence of different species of Mus was also obtained by Wakeland and co-workers (1987) and McConnell and co-workers (1988). Shortly afterwards, nucleotide sequence analysis demonstrated striking similarities between alleles in differ-ent species of primates at both class I (Mayer et al 1988;Lawlor et al 1988, and others) and class II (Fan et al 1989;Gyllensten and Erlich 1989;Gyllensten et al 1991;Kenter et al 1992;Mayer et al 1992;Kupfermann et al 1992;Slierendregt et al 1992, and others) loci. These studies have led to the conclusion that in primates, allelic lineages at some of the polymorphic loci are probably more than 20 my old .…”

CD8+Lymphocytes from Simian Immunodeficiency Virus-Infected Rhesus Macaques Recognize 14 Different Epitopes Bound by the Major Histocompatibility Complex Class I Molecule Mamu-A*01: Implications for Vaccine Design and Testing

“…SIV and HIV have similar tropisms for CD4 (16,36), and infection with SIV causes an AIDS-like disease in the majority of infected macaques by 1 year postinoculation (35). Since macaques and humans have very similar immune systems (10,31,63,76), SIV infection of macaques is also an excellent model to study the immunology of HIV infection of humans.…”