Evolving aphasia: trajectories of neurodegenerative diseases

Abstract

Aphasia, an acquired disorder of language function, may sometimes be an early and isolated sign of neurodegenerative disease or may sometimes evolve in the course of an existing neurodegenerative disorder. We present two cases in which aphasia progressively evolved, one in the context of an existing non‐linguistic cognitive disorder, and one in which aphasia was the presenting symptom. Awareness of the trajectory of neurodegenerative disorders is required when assessing patients longitudinally in clinics devoted to the assessment of cognitive disorders.

The neurology ‐ psychiatry interface: variations on a diagnostic theme

“…• Early behavioural disinhibition The case further emphasises the need for ongoing follow-up of patients with suspected (and definite) 12 neurodegenerative disorders in order to observe illness trajectory and to remain alert to the necessity for diagnostic reconsideration and possibly revision. With the advent of potential disease-modifying therapies for neurodegenerative disorders this will gain increasing relevance.…”