Evolving approaches in glioma treatment: harnessing the potential of copper metabolism modulation

Cazzoli, Riccardo; Zamborlin, Agata; Ermini, Maria Laura; Salerno, Antonietta; Curcio, Manuela; Nicoletta, Fiore Pasquale; Iemma, Francesca; Vittorio, Orazio; Voliani, Valerio; Cirillo, Giuseppe

doi:10.1039/d3ra06434d

RSC Adv.

2023

DOI: 10.1039/d3ra06434d

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Evolving approaches in glioma treatment: harnessing the potential of copper metabolism modulation

Riccardo Cazzoli,

Agata Zamborlin,

Maria Laura Ermini

et al.

Abstract: Copper overload or depletion is a valuable strategy in oncology: copper nanoparticles carry out copper-dependent apoptosis via oxidative stress; copper chelators induce apoptosis, inhibit angiogenesis and tumor progression.

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2024

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Cited by 3 publications

References 134 publications

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The interplay between metal ions and immune cells in glioma: pathways to immune escape

Li,

Mao,

Chen

et al. 2024

Discov Onc

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This review explores the intricate roles of metal ions—iron, copper, zinc, and selenium—in glioma pathogenesis and immune evasion. Dysregulated metal ion metabolism significantly contributes to glioma progression by inducing oxidative stress, promoting angiogenesis, and modulating immune cell functions. Iron accumulation enhances oxidative DNA damage, copper activates hypoxia-inducible factors to stimulate angiogenesis, zinc influences cell proliferation and apoptosis, and selenium modulates the tumor microenvironment through its antioxidant properties. These metal ions also facilitate immune escape by upregulating immune checkpoints and secreting immunosuppressive cytokines. Targeting metal ion pathways with therapeutic strategies such as chelating agents and metalloproteinase inhibitors, particularly in combination with conventional treatments like chemotherapy and immunotherapy, shows promise in improving treatment efficacy and overcoming resistance. Future research should leverage advanced bioinformatics and integrative methodologies to deepen the understanding of metal ion-immune interactions, ultimately identifying novel biomarkers and therapeutic targets to enhance glioma management and patient outcomes.

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The interplay between metal ions and immune cells in glioma: pathways to immune escape

Li,

Mao,

Chen

et al. 2024

Discov Onc

View full text Add to dashboard Cite

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Unveiling Cuproptosis: Mechanistic insights, roles, and leading advances in oncology

Zhang,

Xie,

et al. 2024

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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Role of copper chelating agents: between old applications and new perspectives in neuroscience

Leuci,

Brunetti,

Tufarelli

et al. 2024

Neural Regeneration Research

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The role of copper element has been an Increasingly relevant topic In recent years In the fields of human and animal health, for both the study of new drugs and Innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper (II) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases (such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Finally, seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

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Evolving approaches in glioma treatment: harnessing the potential of copper metabolism modulation

Abstract: Copper overload or depletion is a valuable strategy in oncology: copper nanoparticles carry out copper-dependent apoptosis via oxidative stress; copper chelators induce apoptosis, inhibit angiogenesis and tumor progression.

Cited by 3 publications

References 134 publications

The interplay between metal ions and immune cells in glioma: pathways to immune escape

The interplay between metal ions and immune cells in glioma: pathways to immune escape

Unveiling Cuproptosis: Mechanistic insights, roles, and leading advances in oncology

Role of copper chelating agents: between old applications and new perspectives in neuroscience

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