Evolving Aspects of Prognostic Factors for Pediatric Cancer

Kourti, Maria; Hatzipantelis, Emmanouel

doi:10.3390/diagnostics13233515

Diagnostics

2023

DOI: 10.3390/diagnostics13233515

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Evolving Aspects of Prognostic Factors for Pediatric Cancer

Maria Kourti,

Emmanouel Hatzipantelis

Abstract: Advances in risk-directed therapy based on prognostic factors that include clinical, biologic, and genetic features of cancer in children have yielded improved and prolonged responses [...]

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2024

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Are Pediatric Cancer Patients a Risk Group for Vitamin D Deficiency? A Systematic Review

Alexandru,

Ivan,

Tanasescu

et al. 2024

Cancers

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Background: Vitamin D deficiency is increasingly recognized as a global health concern, with potential implications for cancer development and progression. This systematic review investigated the prevalence of vitamin D deficiency in pediatric cancer patients and its potential impact on clinical outcomes. Methods: A comprehensive literature search was conducted across multiple databases, including PubMed, Web of Science, and Cochrane Library, to identify the relevant studies published between 2009 and July 2024. Studies were included if they assessed vitamin D status in pediatric cancer patients and reported on the clinical outcomes. Data extraction and quality assessment were performed independently by two reviewers. Results: The review included 20 original articles encompassing a diverse pediatric population with various cancer types. A high prevalence of vitamin D deficiency was observed across the studies. Deficiency was associated with older age and lower socioeconomic status. Several studies reported associations between vitamin D deficiency and the increased risk of infection, poorer treatment response, and decreased survival. Conclusions: Vitamin D deficiency is highly prevalent in pediatric cancer patients and may negatively impact clinical outcomes. Routine screening for vitamin D deficiency and personalized supplementation strategies should be considered in this population. Further research is needed to establish optimal vitamin D management protocols and evaluate the long-term benefits of vitamin D repletion in pediatric oncology.

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Are Pediatric Cancer Patients a Risk Group for Vitamin D Deficiency? A Systematic Review

Alexandru,

Ivan,

Tanasescu

et al. 2024

Cancers

View full text Add to dashboard Cite

show abstract

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Evolving Aspects of Prognostic Factors for Pediatric Cancer

Abstract: Advances in risk-directed therapy based on prognostic factors that include clinical, biologic, and genetic features of cancer in children have yielded improved and prolonged responses [...]

Cited by 1 publication

References 20 publications

Are Pediatric Cancer Patients a Risk Group for Vitamin D Deficiency? A Systematic Review

Are Pediatric Cancer Patients a Risk Group for Vitamin D Deficiency? A Systematic Review

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