Evolving criteria for confirmation of trace level residues in food and drugs by mass spectrometry. Part I

Cairns, Thomas; Siegmund, Emil G.; Stamp, John J.

doi:10.1002/mas.1280080203

Cited by 21 publications

(9 citation statements)

References 22 publications

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“…[49][50][51][52][53][54][55][56][57] A number of reviews describing the development of criteria for confirmation using GC/MS, LC/MS, and MS/MS have been published. [58][59][60][61] The original guideline of a minimum of three ions for confirmation has been widely adopted. Today, the majority of confirmations reported in the literature have been performed with three or more ions.…”

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confidence: 99%

Confirmation and Quantitation of Selected Sulfonylurea, Imidazolinone, and Sulfonamide Herbicides in Surface Water Using Electrospray LC/MS

1998

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A multianalyte method has been developed for the confirmation and quantitation of 16 selected sulfonylurea, imidazolinone, and sulfonamide herbicides in surface water. Samples are acidified, the analytes are extracted using RP-102 extraction cartridges, and the extracts are cleaned-up using an anion-exchange cartridge (SAX) stacked on top of an alumina cartridge. The final extracts are evaporated to dryness, redissolved in 10:90 or 20:80 acetonitrile/water, and analyzed using electrospray LC/MS. Confirmation criteria were defined so that identification of the analytes could be made with a reasonable degree of scientific certainty. Confirmation required that (1) LC/MS retention times of the analytes be within 1% of the retention times of the standards, (2) the molecular ion and two characteristic fragment ions per analyte be present, and (3) ion abundance ratios of the fragment ions relative to the molecular ion be within 20% of the ion ratios obtained for the standards. Each of the analytes in all of the samples used to validate this method met these confirmation criteria. Quantitation of the analytes at 0.1 and 1.0 ppb was demonstrated, with average recoveries between 70% and 114% and relative standard deviations that were less than 13%. The limit of quantitation (LOQ) for this method is 0.1 ppb (ng/mL) for all analytes. Six water types were used for the validation of this method.

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confidence: 99%

Confirmation and Quantitation of Selected Sulfonylurea, Imidazolinone, and Sulfonamide Herbicides in Surface Water Using Electrospray LC/MS

1998

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“…Supporting evidence provided by the GC or LC retention time, as well as appropriate sample preparation and clean up, has been recognized as fundamentally important [12] at GC-MS or LC-MS, especially for the analysis of isomers or enantiomers [13]. The probability for overlapping of chromatographic peaks P r,s is determined by the efficiency of the column [14] and the selectivity and the sensitivity of the detector [15].…”

Section: Calculation Of the Probability Of Distinguishing Ms Spectramentioning

confidence: 99%

Quantitative assessment of the reliability of identification by high-performance liquid chromatography–mass spectrometry

Stoev

2004

Journal of Chromatography

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“…high polarity: moving belt interface (MBI) (3), direct liquid introduction (DLI) (4), and, more recently, DLI with supercritical fluid chromatography (5) and thermospray (6). The main driving force behind these various approaches has been the demonstrated practical ability to analyze either thermally labile or nonvolatile compounds.…”

Section: Introductionmentioning

confidence: 99%