Evolving issues in the management of reflux disease?

Yuan, Yuhong; Hunt, Richard H.

doi:10.1097/mog.0b013e32832c1504

Cited by 21 publications

(18 citation statements)

References 95 publications

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“…In addition, outcomes reported at telephone interview may be more favorable, as well as there is a significant risk of bias in reporting of surgical outcomes when incomplete data are analyzed. The limitation inherent to outcome's comparison between different groups applying different data collection has already been outlined [41] and recently it has been strongly recommended the development of validated outcome instruments [42, 43]. …”

Section: Discussionmentioning

confidence: 99%

Evaluation of Clinical Outcome after Laparoscopic Antireflux Surgery in Clinical Practice: Still a Controversial Issue

Contini

Scarpignato

2011

Minimally Invasive Surgery

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Background. Laparoscopic antireflux surgery has shown to be effective in controlling gastroesophageal reflux (GERD). Yet, a universally accepted definition and evaluation for treatment success/failure in GERD is still controversial. The purpose of this paper is to assess if and how the outcome variables used in the different studies could possibly lead to an homogeneous appraisal of the limits and indications of LARS. Methods. We analyzed papers focusing on the efficacy and outcome of LARS and published in English literature over the last 10 years. Results. Symptoms scores and outcome variables reported are dissimilar and not uniform. The most consistent parameter was patient's satisfaction (mean satisfaction rate: 88.9%). Antireflux medications are not a trustworthy outcome index. Endoscopy and esophageal manometry do not appear very helpful. Twenty-four hours pH metry is recommended in patients difficult to manage for recurrent typical symptoms. Conclusions. More uniform symptoms scales and quality of life tools are needed for assessing the clinical outcome after laparoscopic antireflux surgery. In an era of cost containment, objective evaluation tests should be more specifically addressed. Relying on patient's satisfaction may be ambiguous, yet from this study it can be considered a practical and simple tool.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Clinical Outcome after Laparoscopic Antireflux Surgery in Clinical Practice: Still a Controversial Issue

Contini

Scarpignato

2011

Minimally Invasive Surgery

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“…Studies in healthy volunteers [135,136], have shown that tenatoprazole, and even more so its S-enantiomer [137], are capable of inducing very potent and sustained gastric acid inhibition, significantly better than that obtained with the PPI comparator (esomeprazole at 40 mg qd or bid). This difference was most pronounced during the night [136,138]. How this better pharmacological profile (Fig.…”

Section: Potassiumcompetitive Inhibition K+mentioning

confidence: 83%

Short and long-term PPI treatment for GERD. Do we need more-potent anti-secretory drugs?

Varannes

Coron

Galmiche

2010

Best Practice & Research Clinical Gastroenterology

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“…Most authors define it as an ongoing impairment of GERD‐related quality of life despite the use of once‐ or twice‐daily PPI therapy. These refractory symptoms may or may not be acid related, possibly reflecting increased refluxate volume (so‐called volume reflux), altered esophageal distensibility, or even enhanced sensitivity to acid, among other possibilities . In such instances, the use of tricyclics, selective serotonin reuptake inhibitors (SSRIs), prokinetics, sucralfate, and other agents not merely aimed at acid suppression may be successful in containing the patient's symptoms.…”

Section: Refractory Gerd and The Gerd Treatment Gapmentioning

confidence: 99%

How can we deal with the GERD treatment gap?

Triadafilopoulos

Azagury

2016

Annals of the New York Academy of Sciences

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Patients experiencing heartburn and acid regurgitation despite proton pump inhibition therapy who are averse to antireflux surgery fall into what is called the gastroesophageal reflux disease (GERD) treatment gap. This gap may be potentially addressed by several endoscopic and laparoscopic techniques, including gastric bypass surgery for those patients who are obese. These novel techniques do not significantly alter the anatomy of the esophagogastric junction, minimizing short- and long-term adverse effects. This review provides an overview of the assessment of patients with refractory GERD and highlights the strengths and weaknesses of these minimally invasive therapies.

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Evolving issues in the management of reflux disease?

Cited by 21 publications

References 95 publications

Evaluation of Clinical Outcome after Laparoscopic Antireflux Surgery in Clinical Practice: Still a Controversial Issue

Evaluation of Clinical Outcome after Laparoscopic Antireflux Surgery in Clinical Practice: Still a Controversial Issue

Short and long-term PPI treatment for GERD. Do we need more-potent anti-secretory drugs?

How can we deal with the GERD treatment gap?

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